BACKGROUND: The continuing search for the ideal dural substitute is currently directed toward collagen preparations. Xenogeneic porcine small intestinal submucosa (SIS), a naturally occurring extracellular matrix rich in collagen, has been successfully used as a soft tissue graft in several body organ systems, including preliminary studies as a dural substitute in the rat. METHODS: Eight dogs underwent temporoparietal craniotomy and dural resection with replacement by SIS. Five dogs had contralateral procedures without SIS grafting. Three dogs had contralateral SIS grafts placed 2 months after the initial procedure. Histologic assessment was obtained at 7, 30, 60, 90, and 120 days. Cerebrospinal fluid (CSF) cytological examination and routine serum chemistry preceded sacrifice. RESULTS: Histologic evaluation showed initial graft infiltration by mononuclear round cells, spindle-shaped cells within an eosinophilic staining extracellular matrix, and neovascularity. Complete resorption of the graft was evident by 60 days. This pattern is consistent with the previously described incorporation and remodeling of the SIS graft at other sites. CSF cytology and routine serum chemistry at the time of sacrifice were normal. Response to repeat grafting was identical to that of initial exposure. There was no clinical or histologic evidence of sensitization or graft rejection. No evidence of adverse effect on the underlying cerebral cortex was observed. CONCLUSIONS: Porcine small intestinal submucosa demonstrates a favorable biologic response as a dural substitute in the canine model. It is a promising biomaterial for dural replacement.
BACKGROUND: The continuing search for the ideal dural substitute is currently directed toward collagen preparations. Xenogeneic porcine small intestinal submucosa (SIS), a naturally occurring extracellular matrix rich in collagen, has been successfully used as a soft tissue graft in several body organ systems, including preliminary studies as a dural substitute in the rat. METHODS: Eight dogs underwent temporoparietal craniotomy and dural resection with replacement by SIS. Five dogs had contralateral procedures without SIS grafting. Three dogs had contralateral SIS grafts placed 2 months after the initial procedure. Histologic assessment was obtained at 7, 30, 60, 90, and 120 days. Cerebrospinal fluid (CSF) cytological examination and routine serum chemistry preceded sacrifice. RESULTS: Histologic evaluation showed initial graft infiltration by mononuclear round cells, spindle-shaped cells within an eosinophilic staining extracellular matrix, and neovascularity. Complete resorption of the graft was evident by 60 days. This pattern is consistent with the previously described incorporation and remodeling of the SIS graft at other sites. CSF cytology and routine serum chemistry at the time of sacrifice were normal. Response to repeat grafting was identical to that of initial exposure. There was no clinical or histologic evidence of sensitization or graft rejection. No evidence of adverse effect on the underlying cerebral cortex was observed. CONCLUSIONS: Porcine small intestinal submucosa demonstrates a favorable biologic response as a dural substitute in the canine model. It is a promising biomaterial for dural replacement.
Authors: Sebastian G de la Fuente; Marcia R Gottfried; D Curtis Lawson; Mary B Harris; Christopher R Mantyh; Theodore N Pappas Journal: J Gastrointest Surg Date: 2003-01 Impact factor: 3.452
Authors: Mark H Murdock; Sherin David; Ilea T Swinehart; Janet E Reing; Kien Tran; Kathrin Gassei; Kyle E Orwig; Stephen F Badylak Journal: Tissue Eng Part A Date: 2019-04 Impact factor: 3.845
Authors: Daniel H Shell; Martin A Croce; Catherine Cagiannos; T Wright Jernigan; Norma Edwards; Timothy C Fabian Journal: Ann Surg Date: 2005-06 Impact factor: 12.969
Authors: Ellen Bible; Flavio Dell'Acqua; Bhavana Solanky; Anthony Balducci; Peter M Crapo; Stephen F Badylak; Eric T Ahrens; Michel Modo Journal: Biomaterials Date: 2012-01-13 Impact factor: 15.304
Authors: Laura Teodori; Alessandra Costa; Rosa Marzio; Barbara Perniconi; Dario Coletti; Sergio Adamo; Bhuvanesh Gupta; Attila Tarnok Journal: Front Physiol Date: 2014-06-16 Impact factor: 4.566
Authors: Kundandeep S Nagi; Ricardo J Cumba; Nicholas P Bell; Lauren S Blieden; Alice Z Chuang; Kimberly A Mankiewicz; Donna Nguyen; Robert M Feldman Journal: J Ophthalmol Date: 2013-03-17 Impact factor: 1.909