CASE REPORT: A case history of unanticipated radiation-induced bilateral optic neuropathy, 18 months after induction chemotherapy and radiation therapy for a locally advanced nasopharyngeal carcinoma, is presented. Retrospective reanalysis of the radiation therapy technique, with emphasis on the doses received by the optic pathway structures, was performed. These re-calculations revealed unexpectedly high doses in the range 79 to 82 Gy (cumulative external and brachytherapy dose) at the level of the optic nerves, which explained the observed radiation injury. CONCLUSION: Routine implementation of computed tomography for 3D dose planning purposes is therefore advocated. Review of the current literature confirms the importance of 3D dose planning in avoiding this complication and high-lights the role of MRI in establishing the diagnosis of radiation-induced optic neuropathy.
CASE REPORT: A case history of unanticipated radiation-induced bilateral optic neuropathy, 18 months after induction chemotherapy and radiation therapy for a locally advanced nasopharyngeal carcinoma, is presented. Retrospective reanalysis of the radiation therapy technique, with emphasis on the doses received by the optic pathway structures, was performed. These re-calculations revealed unexpectedly high doses in the range 79 to 82 Gy (cumulative external and brachytherapy dose) at the level of the optic nerves, which explained the observed radiation injury. CONCLUSION: Routine implementation of computed tomography for 3D dose planning purposes is therefore advocated. Review of the current literature confirms the importance of 3D dose planning in avoiding this complication and high-lights the role of MRI in establishing the diagnosis of radiation-induced optic neuropathy.
Authors: M M Urie; B Fullerton; H Tatsuzaki; S Birnbaum; H D Suit; K Convery; S Skates; M Goitein Journal: Int J Radiat Oncol Biol Phys Date: 1992 Impact factor: 7.038
Authors: C A Perez; V R Devineni; V Marcial-Vega; J E Marks; J R Simpson; N Kucik Journal: Int J Radiat Oncol Biol Phys Date: 1992 Impact factor: 7.038
Authors: S A Leibel; G J Kutcher; L B Harrison; D E Fass; C M Burman; M A Hunt; R Mohan; L J Brewster; C C Ling; Z Y Fuks Journal: Int J Radiat Oncol Biol Phys Date: 1991-04 Impact factor: 7.038
Authors: J Guy; A Mancuso; R Beck; M L Moster; L A Sedwick; R G Quisling; A L Rhoton; E E Protzko; J Schiffman Journal: J Neurosurg Date: 1991-03 Impact factor: 5.115