Literature DB >> 9950

Isoprenaline antagonism of cardioselective beta-adrenergic receptor blocking agents on human and rat adipocytes.

H H Harms, J Van der Meer.   

Abstract

1. The beta-adrenergic blocking potencies of practolol, ICI 66082, tolamolol, acebutolol, H 93/26, H 87/07, pindolol and Ro 3-4787 were compared with that of propranolol, on human and rat adipocytes. 2. A good correlation was found between the potencies on adipocytes of the two species but not between our results and literature data on antagonism of isopernaline tachycardia in the anaesthetized cat. 3. The results indicate that differences between adrenergic beta-receptors in heart and adipose tissue may be detected using cardioselective beta-adrenergic receptor blocking agents.

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Year:  1975        PMID： 9950      PMCID： PMC1402598          DOI： 10.1111/j.1365-2125.1975.tb02776.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  16 in total

1.  METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS.

Authors:  M RODBELL
Journal:  J Biol Chem       Date:  1964-02       Impact factor: 5.157

2.  Adrenoceptors mediating metabolic responses in the greyhound.

Authors:  J G Kelly; R G Shanks
Journal:  Br J Pharmacol       Date:  1971-02       Impact factor: 8.739

3.  Pharmacological studies of two new cardioselective adrenergic beta-receptor antagonists.

Authors:  B Ablad; E Carlsson; L Ek
Journal:  Life Sci I       Date:  1973-02-01

4.  A new type of cardioselective adrenoceptive blocking drug.

Authors:  A M Barrett; J Carter; J D Fitzgerald; R Hull; D Le Count
Journal:  Br J Pharmacol       Date:  1973-06       Impact factor: 8.739

Review 5.  Differentiation of receptors activated by catecholamines. 3.

Authors:  A Arnold
Journal:  Farmaco Sci       Date:  1972-01

6.  Beta-adrenoceptor studies. III. On the beta-adrenoceptors in rat adipose tissue.

Authors:  H H Harms; J Zaagsma; B Van der Wal
Journal:  Eur J Pharmacol       Date:  1974-01       Impact factor: 4.432

7.  Selectivity of beta-adrenergic compounds. III - Classification of beta-receptors.

Authors:  E Grana; A Lucchelli; F Zonta
Journal:  Farmaco Sci       Date:  1974-10

8.  A comparison of the activities of the beta-adrenoceptor agonists MJ9184-1 AND (--)-ISOPRENALINE IN GUINEA-PIG AND CAT PREPARATIONS.

Authors:  T Davey; E Malta; C Raper
Journal:  Clin Exp Pharmacol Physiol       Date:  1974 Jan-Feb       Impact factor: 2.557

9.  The beta-blocking potency and cardioselectivity of tolamolol and its isomers in rodents.

Authors:  K R Adam; J R Baird; R A Burges; J Linnell
Journal:  Eur J Pharmacol       Date:  1974-02       Impact factor: 4.432

10.  Beta-adrenoceptor blocking properties and cardioselectivity of M & B 17,803A.

Authors:  B Basil; R Jordan; A H Loveless; D R Maxwell
Journal:  Br J Pharmacol       Date:  1973-06       Impact factor: 8.739
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  5 in total

Review 1.  Hypertension: which beta-blocker?

Authors:  H J Waal-Manning
Journal:  Drugs       Date:  1976-12       Impact factor: 9.546

2.  Blockade of isoprenaline-induced changes in plasma free fatty acids, immunoreactive insulin levels and plasma renin activity in healthy human subjects, by propranolol, pindolol, practolol, atenolol, metoprolol and acebutolol.

Authors:  H H Harms; L Gooren; A J Spoelstra; C Hesse; L Verschoor
Journal:  Br J Clin Pharmacol       Date:  1978-01       Impact factor: 4.335

3.  Atypical characteristics of the beta-adrenoceptor mediating cyclic AMP generation and lipolysis in the rat adipocyte.

Authors:  D Bojanic; J D Jansen; S R Nahorski; J Zaagsma
Journal:  Br J Pharmacol       Date:  1985-01       Impact factor: 8.739

Review 4.  Beta-adrenoceptor blocking agents and lipolysis.

Authors:  H H Harms; J De Vente; J Zaagsma
Journal:  Br J Clin Pharmacol       Date:  1982       Impact factor: 4.335

5.  A comparison between propranolol, practolol and betaxolol (SL75212) on the circulatory and metabolic responses to insulin-induced hypoglycaemia.

Authors:  J Saunders; R Gomeni; J R Kilborn; P L Morselli; P H Sönksen
Journal:  Eur J Clin Pharmacol       Date:  1981       Impact factor: 2.953
  5 in total

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