Literature DB >> 994740

Inhibition of acid esterase in rat liver by 4,4'-diethylamino-ethoxyhexestrol.

K Kasama, K Yoshida, S Takeda, R Tsujimura, S Hasegawa.   

Abstract

The effect of 4,4'-diethylamino-ethoxyhexestrol (DH) on acid esterase in rat liver was studied in vivo and in vitro. The acid esterase activity in the livers of rats treated with 0.125% DH for 1 week was found to decrease more than 60% as compared with that in untreated rats. The addition of DH to the incubation medium caused considerable inhibition of the acid esterase activity in lysosome from untreated rat liver, and the inhibition type appears to be noncompetitive. The acid lipase activity in rat liver lysosome was also inhibited by DH. Some antihistamic agents and chloroquine also inhibited the acid esterase activity in rat liver lysosome.

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Year:  1976        PMID： 994740     DOI： 10.1007/bf02533044

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  21 in total

1.  Tissue fractionation studies. 4. Comparative study of the binding of acid phosphatase, beta-glucuronidase and cathepsin by rat-liver particles.

Authors:  R GIANETTO; C DE DUVE
Journal:  Biochem J       Date:  1955-03       Impact factor: 3.857

2.  A simple method for the isolation and purification of total lipides from animal tissues.

Authors:  J FOLCH; M LEES; G H SLOANE STANLEY
Journal:  J Biol Chem       Date:  1957-05       Impact factor: 5.157

3.  Enzymatic metabolism of drugs and other foreign compounds.

Authors:  B B BRODIE; J R GILLETTE; B N LA DU
Journal:  Annu Rev Biochem       Date:  1958       Impact factor: 23.643

4.  The determination of enzyme inhibitor constants.

Authors:  M DIXON
Journal:  Biochem J       Date:  1953-08       Impact factor: 3.857

5.  The colorimetric micro-determination of long-chain fatty acids.

Authors:  W G Duncombe
Journal:  Biochem J       Date:  1963-07       Impact factor: 3.857

6.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

7.  Bis-(monoacylglyceryl)phosphate and acyl phosphatidylglycerol isolated from human livers of lipidosis induced by 4,4'-diethylaminoethoxyhexesterol.

Authors:  K Kasama; K Yoshida; S Takeda; S Akeda; K Kawai
Journal:  Lipids       Date:  1974-04       Impact factor: 1.880

8.  Studies on drug-induced lipodosis. V. Changes in the lipid composition of rat liver and spleen following the administration of 4,4'-diethylaminoethoxyhexestrol.

Authors:  S Adachi; Y Matsuzawa; T Yokomura; K Ishikawa; S Uhara
Journal:  Lipids       Date:  1972-01       Impact factor: 1.880

9.  Hydrolysis of higher fatty acid esters of p-nitrophenol by rat liver and kidney lysosomes.

Authors:  S Mahadevan; A L Tappel
Journal:  Arch Biochem Biophys       Date:  1968-09-10       Impact factor: 4.013

10.  Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease.

Authors:  J L Goldstein; S E Dana; J R Faust; A L Beaudet; M S Brown
Journal:  J Biol Chem       Date:  1975-11-10       Impact factor: 5.157
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  1 in total

Review 1.  Pulmonary and generalized lysosomal storage induced by amphiphilic drugs.

Authors:  Z Hruban
Journal:  Environ Health Perspect       Date:  1984-04       Impact factor: 9.031
  1 in total

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