Literature DB >> 994008

Enhancement of dissolution rates of poorly water-soluble drugs by crystallization in aqueous surfactant solutions I: Sulfathiazole, prednisone, and chloramphenicol.

W L Chiou, S J Chen, N Athanikar.   

Abstract

Effects of crystallization of poorly water-soluble drugs in aqueous surfactant solution on in vitro dissolution rates were investigated. Marked enhancement was observed for chloramphenicol, sulfathiazole, and prednisone. Differential thermal analysis studies indicated the presence of small amounts of surfactant in surfactant-treated crystals. Possible mechanisms of dissolution enhancement are discussed.

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Year:  1976        PMID： 994008     DOI： 10.1002/jps.2600651137

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  4 in total

1.  The influence of the crystallization on the properties of a hydrophobic drug.

Authors:  A Ludwig; M Van Ooteghem
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2.  Exemestane loaded self-microemulsifying drug delivery system (SMEDDS): development and optimization.

Authors:  Ajeet K Singh; Akash Chaurasiya; Manish Singh; Satish C Upadhyay; Rama Mukherjee; Roop K Khar
Journal:  AAPS PharmSciTech       Date:  2008-05-13       Impact factor: 3.246

3.  Effects of surfactants on amiodarone intestinal absorption. I. Sodium laurylsulfate.

Authors:  R V Martín-Algarra; R M Pascual-Costa; M Merino; V G Casabó
Journal:  Pharm Res       Date:  1994-07       Impact factor: 4.200

4.  Development of prednisone:polyethylene glycol 6000 fast-release tablets from solid dispersions: solid-state characterization, dissolution behavior, and formulation parameters.

Authors:  Darío Leonardi; María Gabriela Barrera; María Celina Lamas; Claudio Javier Salomón
Journal:  AAPS PharmSciTech       Date:  2007-12-14       Impact factor: 3.246
  4 in total

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