Literature DB >> 993810

Effects of a carbonic anhydrase inhibitor on cerebral blood flow in geriatric patients.

D J Wyper, C J McAlpine, K Jawad, B Jennett.   

Abstract

A carbonic anhydrase inhibitor (UK-12,130) was shown to increase cerebral blood flow in mildly demented geriatric patients. Oral administration caused a significant increase in blood flow at two different dose levels; this persisted for at least six weeks, which was the duration of the longest study. There was no consistent improvement in mentation during treatment. Blood blow was measured by the washout of 133Xe after inhalation of this inert gas.

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Year:  1976        PMID： 993810      PMCID： PMC492477          DOI： 10.1136/jnnp.39.9.885

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  9 in total

1.  The relation between enzyme inhibition and physiological response in the carbonic anhydrase system.

Authors:  T H MAREN
Journal:  J Pharmacol Exp Ther       Date:  1963-02       Impact factor: 4.030

2.  The toxic effects of carbon dioxide and acetazolamide in hepatic encephalopathy.

Authors:  J B POSNER; F PLUM
Journal:  J Clin Invest       Date:  1960-08       Impact factor: 14.808

Review 3.  Carbonic anhydrase: chemistry, physiology, and inhibition.

Authors:  T H Maren
Journal:  Physiol Rev       Date:  1967-10       Impact factor: 37.312

4.  Effects of acetazolamide on cerebral blood flow of dogs during hyperbaric oxygenation.

Authors:  Y Kong; S Lunzer; A Heyman; H K Thompson; H A Saltzman
Journal:  Am Heart J       Date:  1969-08       Impact factor: 4.749

5.  The effects of acetazolamide on cerebral blood flow and cerebral tissue PO2.

Authors:  S Cotev; J Lee; J W Severinghaus
Journal:  Anesthesiology       Date:  1968 May-Jun       Impact factor: 7.892

6.  Brain extracellular pH: the main factor controlling cerebral blood flow.

Authors:  N A Lassen
Journal:  Scand J Clin Lab Invest       Date:  1968-12       Impact factor: 1.713

7.  Carbonic anhydrase inhibition and cerebral venous blood gases and ions in man. Demonstration of increased oxygen availability to ischemic brain.

Authors:  F Gotoh; J S Meyer; M Tomita
Journal:  Arch Intern Med       Date:  1966-01

8.  Step hypocapnia to separate arterial from tissue PCO2 in the regulation of cerebral blood flow.

Authors:  J W Severinghaus; N Lassen
Journal:  Circ Res       Date:  1967-02       Impact factor: 17.367

9.  Two minute slope inhalation technique for cerebral blood flow measurement in man. 2. Clinical appraisal.

Authors:  D J Wyper; G A Lennox; J O Rowan
Journal:  J Neurol Neurosurg Psychiatry       Date:  1976-02       Impact factor: 10.154
  9 in total

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