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Literature DB >> 993793

Insulin coma therapy: decrease of plasma tryptophan in man.

Abstract

A biochemical study was performed in two patients submitted to insulin coma therapy. The injection of insulin resulted in a decrease of free and total tryptophan as well as tyrosine in plasma, while NEFA were not influenced by this treatment. The ratio of tryptophan to tyrosine was enhanced. The administration of glucose after insulin provoked an increase of free and total tryptophan. The results support the hypothesis that in man insulin may favor the uptake of tryptophan by the brain, and enhance the synthesis of cerebral serotonin.

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Year: 1976 PMID： 993793 DOI： 10.1007/bf01266307

Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575

17 in total

1. Induction of tryptophan peroxidase of rat liver by insulin and alloxan.

Authors: J M SCHOR; E FRIEDEN
Journal: J Biol Chem Date: 1958-09 Impact factor: 5.157

2. Letter: Dietary carbohydrate increases brain tryptophan and decreases free plasma tryptophan.

Authors: B K Madras; E L Cohen; J D Fernstrom; F Larin; H N Munro; R J Wurtman
Journal: Nature Date: 1973-07-06 Impact factor: 49.962

3. Dietary regulation of brain tryptophan metabolism by plasma ratio of free tryptophan and neutral amino acids in humans.

Authors: J Pérez-Cruet; T N Chase; D L Murphy
Journal: Nature Date: 1974-04-19 Impact factor: 49.962

4. Determination of free and bound plasma tryptophan by ultrafiltration.

Authors: P Baumann; E Duruz; H Heimann
Journal: Clin Chim Acta Date: 1974-02-28 Impact factor: 3.786

5. Serum tryptophan level after carbohydrate ingestion: selective decline in non-albumin-bound tryptophan coincident with reduction in serum free fatty acids.

Authors: D Lipsett; B K Madras; R J Wurtman; H N Munro
Journal: Life Sci II Date: 1973-01-22

9. Effects on plasma and brain tryptophan in the rat of drugs and hormones that influence the concentration of unesterified fatty acid in the plasma.

Authors: G Curzon; P J Knott
Journal: Br J Pharmacol Date: 1974-02 Impact factor: 8.739

10. Amino acid balance across tissues of the forearm in postabsorptive man. Effects of insulin at two dose levels.

Authors: T Pozefsky; P Felig; J D Tobin; J S Soeldner; G F Cahill
Journal: J Clin Invest Date: 1969-12 Impact factor: 14.808

1 in total

1. Profile: Dr Bourne's identity - credit where credit's due.

Authors: Jonathan Pimm
Journal: Psychiatr Bull (2014) Date: 2014-04