Literature DB >> 9935224

Microsatellite analysis reveals deletion of a large region at chromosome 8p in conventional renal cell carcinoma.

D Schullerus1, R von Knobloch, J Chudek, J Herbers, G Kovacs.   

Abstract

Loss of heterozygosity (LOH) at chromosome 8p is associated with the progression of conventional (non-papillary) renal cell carcinomas (RCC). To determine the tumor suppressor gene locus, we carried out a deletion mapping of chromosome 8p at 10 microsatellite loci in 96 RCCs. LOH occurred in 32% of the tumors. The smallest overlapping region of deletion at chromosome 8p11.2-p23.1 corresponds to approximately 34-cM genetic distance. No small interstitial deletion was seen.

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Year:  1999        PMID： 9935224     DOI： 10.1002/(sici)1097-0215(19990105)80:1<22::aid-ijc5>3.0.co;2-s

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  7 in total

1.  Human alpha-defensins HNPs-1, -2, and -3 in renal cell carcinoma: influences on tumor cell proliferation.

Authors:  Claudia A Müller; Jasmina Markovic-Lipkovski; Tatjana Klatt; Jutta Gamper; Gerold Schwarz; Hermann Beck; Martin Deeg; Hubert Kalbacher; Susanne Widmann; Johannes T Wessels; Volker Becker; Gerhard A Müller; Thomas Flad
Journal:  Am J Pathol       Date:  2002-04       Impact factor: 4.307

2.  High telomerase activity correlates with the stabilities of genome and DNA ploidy in renal cell carcinoma.

Authors:  Hideki Izumi; Takahiko Hara; Atsunori Oga; Kenji Matsuda; Yuko Sato; Katsusuke Naito; Kohsuke Sasaki
Journal:  Neoplasia       Date:  2002 Mar-Apr       Impact factor: 5.715

Review 3.  [Cytogenetic alterations in renal tumors. Applications for comparative genomic hybridization and fluorescence in situ hybridization].

Authors:  K D Mertz; J Tchinda; R Küfer; P Möller; M A Rubin; H Moch; S Perner
Journal:  Urologe A       Date:  2006-03       Impact factor: 0.639

4.  Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence.

Authors:  Stefan Taudien; Petra Galgoczy; Klaus Huse; Kathrin Reichwald; Markus Schilhabel; Karol Szafranski; Atsushi Shimizu; Shuichi Asakawa; Adam Frankish; Ivan F Loncarevic; Nobuyoshi Shimizu; Roman Siddiqui; Matthias Platzer
Journal:  BMC Genomics       Date:  2004-12-10       Impact factor: 3.969

5.  Down-regulation of Lsm1 is involved in human prostate cancer progression.

Authors:  S Takahashi; S Suzuki; S Inaguma; Y-M Cho; Y Ikeda; N Hayashi; T Inoue; Y Sugimura; N Nishiyama; T Fujita; T Ushijima; T Shirai
Journal:  Br J Cancer       Date:  2002-03-18       Impact factor: 7.640

6.  Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome.

Authors:  Clara Amid; Linda M Rehaume; Kelly L Brown; James G R Gilbert; Gordon Dougan; Robert E W Hancock; Jennifer L Harrow
Journal:  BMC Genomics       Date:  2009-12-15       Impact factor: 3.969

Review 7.  Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms.

Authors:  Ning Yi Yap; Retnagowri Rajandram; Keng Lim Ng; Jayalakshmi Pailoor; Ahmad Fadzli; Glenda Carolyn Gobe
Journal:  Biomed Res Int       Date:  2015-09-13       Impact factor: 3.411
  7 in total

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