| Literature DB >> 9934485 |
F G Salituro1, C T Baker, J J Court, D D Deininger, E E Kim, B Li, P M Novak, B G Rao, S Pazhanisamy, M D Porter, W C Schairer, R D Tung.
Abstract
A set of HIV protease inhibitors represented by compound 2 has previously been described. Structural and conformational analysis of this compound suggested that conformational restriction of the P1/P2 portion of the molecule could lead to a novel set of potent protease inhibitors. Thus, probe compounds 3-7 were designed, synthesized, and found to be potent inhibitors of HIV protease.Mesh：
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Year: 1998 PMID： 9934485 DOI： 10.1016/s0960-894x(98)00670-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823