| Literature DB >> 9934481 |
W Han1, J C Pelletier, C N Hodge.
Abstract
A new class of tricyclic ureas containing a conformationally constrained proline was designed with the aid of molecular modeling. Efficient stereoselective intermolecular pinacol coupling represented the highlight of the synthesis. These rigid cyclic ureas are active towards HIV-1 protease, with 9 being the most potent compound (Ki = 9 nM) despite interacting with only three side chain binding pockets of HIV protease.Entities:
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Year: 1998 PMID： 9934481 DOI： 10.1016/s0960-894x(98)00659-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823