| Literature DB >> 9934462 |
J Lee1, M K Kang, M W Chun, Y J Jo, J H Kwak, S Kim.
Abstract
A series of methionine analogues have been synthesized as inhibitors of methionyl-tRNA synthetase and evaluated for their inhibitory activities of E. coli methionyl-tRNA synthetase and bacterial growth. Among them, L-methionine hydroxamate 20 has proved to be the best inhibitor of the enzyme with Ki = 19 microM and showed a growth inhibition against E.coli JM 109, P. vulganis 6059 and C. freundii 8090.Entities:
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Year: 1998 PMID： 9934462 DOI： 10.1016/s0960-894x(98)00642-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823