| Literature DB >> 9934456 |
T Fujioka1, M Yamamoto, Y Kashiwada, H Fujii, K Mihashi, Y Ikeshiro, I S Chen, K H Lee.
Abstract
Three novel diterpenes, dysokusones A (1), B (2), and C (3), were isolated from the stem of Dysoxylum kuskusense as cytotoxic substances. The structures were established by spectroscopic examinations. Compounds 1, 2, and 3 were cytotoxic toward HL-60(TB) cells with EC50 values of 2.25, 6.35, and 2.37 microM, respectively. Compound 1 also displayed cytotoxicity against K-562 and NCI-H522 cells with EC50 values of 5.04 and 4.80 microM, respectively.Entities:
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Year: 1998 PMID： 9934456 DOI： 10.1016/s0960-894x(98)00630-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823