Literature DB >> 9933165

Single-channel recording of a store-operated Ca2+ channel in Jurkat T lymphocytes.

H H Kerschbaum1, M D Cahalan.   

Abstract

In T lymphocytes, a store-operated calcium ion (Ca2+) entry mechanism termed the calcium release-activated Ca2+ channel (CRAC channel) underlies the sustained or oscillatory intracellular calcium concentration signal required for interleukin-2 gene expression and cell proliferation. The use of sodium ions as a current carrier enabled single-channel recordings of CRAC channels during activation, inactivation, and blockade of current in the presence of divalent cations. A large conductance of 36 to 40 picosiemens indicates that 100 to 400 CRAC channels are present in T lymphocytes.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 9933165     DOI： 10.1126/science.283.5403.836

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  38 in total

1.  On the characterisation of the mechanism underlying passive activation of the Ca2+ release-activated Ca2+ current ICRAC in rat basophilic leukaemia cells.

Authors:  L Fierro; A B Parekh
Journal:  J Physiol       Date:  1999-10-15       Impact factor: 5.182

2.  Microdomains of high calcium are not required for exocytosis in RBL-2H3 mucosal mast cells.

Authors:  S F Mahmoud; C Fewtrell
Journal:  J Cell Biol       Date:  2001-04-16       Impact factor: 10.539

3.  Two Ca2+ entry pathways mediate InsP3-sensitive store refilling in guinea-pig colonic smooth muscle.

Authors:  J G McCarron; E R Flynn; K N Bradley; T C Muir
Journal:  J Physiol       Date:  2000-05-15       Impact factor: 5.182

4.  Voltage-dependent conductance changes in the store-operated Ca2+ current ICRAC in rat basophilic leukaemia cells.

Authors:  D Bakowski; A B Parekh
Journal:  J Physiol       Date:  2000-12-01       Impact factor: 5.182

Review 5.  Calcium channels in lymphocytes.

Authors:  G Grafton; L Thwaite
Journal:  Immunology       Date:  2001-10       Impact factor: 7.397

Review 6.  Molecular properties and physiological roles of ion channels in the immune system.

Authors:  M D Cahalan; H Wulff; K G Chandy
Journal:  J Clin Immunol       Date:  2001-07       Impact factor: 8.317

Review 7.  Store-Operated Calcium Channels.

Authors:  Murali Prakriya; Richard S Lewis
Journal:  Physiol Rev       Date:  2015-10       Impact factor: 37.312

8.  Regulation of CRAC channel activity by recruitment of silent channels to a high open-probability gating mode.

Authors:  Murali Prakriya; Richard S Lewis
Journal:  J Gen Physiol       Date:  2006-09       Impact factor: 4.086

Review 9.  Functional role of TRPC channels in the regulation of endothelial permeability.

Authors:  Gias U Ahmmed; Asrar B Malik
Journal:  Pflugers Arch       Date:  2005-06-30       Impact factor: 3.657

10.  The store-operated calcium entry pathways in human carcinoma A431 cells: functional properties and activation mechanisms.

Authors:  Konstantin Gusev; Lyuba Glouchankova; Alexander Zubov; Elena Kaznacheyeva; Zhengnan Wang; Ilya Bezprozvanny; Galina N Mozhayeva
Journal:  J Gen Physiol       Date:  2003-07       Impact factor: 4.086
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.