| Literature DB >> 9931537 |
M Duval1, O Fenneteau, V Doireau, A Faye, D Emilie, P Yotnda, J C Drapier, N Schlegel, G Sterkers, H O de Baulny, E Vilmer.
Abstract
We describe 4 cases of lysinuric protein intolerance, which all fulfilled the diagnostic criteria for hemophagocytic lymphohistiocytosis. Mature histiocytes and neutrophil precursors participated in hemophagocytosis in the bone marrow. Moreover, serum levels of ferritin and lactate dehydrogenase were elevated, hypercytokinemia was present, and soluble interleukin-2 receptor levels were increased up to 18.6-fold. The diagnosis of lysinuric protein intolerance should therefore be considered in any patient presenting with hemophagocytic lymphohistiocytosis.Entities:
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Year: 1999 PMID： 9931537 DOI： 10.1016/s0022-3476(99)70423-3
Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406