| Literature DB >> 9931475 |
N Seki1, A Hattori, A Hayashi, S Kozuma, M Ohira, T Hori, T Saito.
Abstract
A novel DNA-PKcs interacting protein, KIP (kinase interacting protein), was recently isolated using a two-hybrid analysis which showed a significant homology to calcineurin B. We found other ESTs showing significant similarity to KIP gene in the dbEST database and isolated a cDNA clone which encodes a 187 amino acid polypeptide from a human fetal brain cDNA library. This protein (termed KIP2 for kinase interacting protein 2) has sequence homology to KIP (46% identical and 64% similarity). RT-PCR analysis showed that the messenger RNA was ubiquitously expressed in various human tissues. Based on PCR-based analysis with a radiation hybrid cell panel and fluorescence in situ hybridization, the gene was localized to the q24 region of chromosome 15.Entities:
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Year: 1999 PMID： 9931475 DOI： 10.1016/s0167-4781(98)00253-x
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002