BACKGROUND: Although the diagnostic value of troponin-T in childhood is documented, little is known about the significance of troponin-I. It was the aim of this study to compare the diagnostic value of troponin-I and troponin-T in children and newborns to assess the perioperative potential myocardial damage. METHODS: Forty-eight children, mean, 51+/-54 months (mean value +/-1 standard deviation) (range, 1 day to 204 months) undergoing cardiac operation were prospectively enrolled in the present study. Troponin-I, troponin-T, creatine kinase (CK), and the MB isoenzyme were measured before operation and postoperatively within 2 days. RESULTS: Postoperative values of troponin-I for children undergoing extracardiac operation were in the normal range. In children with interventions through the right atrium (n = 10) the mean value increase to 6.5+/-6.1 microg/L (range, 1.8 to 24.3 microg/L) and even to a mean of 29.9+/-21.1 microg/L (range, 7.5 to 90 microg/L) (p<0.01) in children with atrial and additional ventricular surgical approach (n = 23). Troponin-I was of equal specificity and sensitivity compared to troponin-T, excepted in patients with postoperative renal failure in whom troponin-T raised to false pathological results. CONCLUSIONS: For detection of perioperative myocardial damage troponin-I shows a higher specificity than CK-MB activity and CK-MB mass. The diagnostic value of troponin-I is similar to troponin-T, but compared with troponin-T, it has the advantage of not being influenced by renal failure.
BACKGROUND: Although the diagnostic value of troponin-T in childhood is documented, little is known about the significance of troponin-I. It was the aim of this study to compare the diagnostic value of troponin-I and troponin-T in children and newborns to assess the perioperative potential myocardial damage. METHODS: Forty-eight children, mean, 51+/-54 months (mean value +/-1 standard deviation) (range, 1 day to 204 months) undergoing cardiac operation were prospectively enrolled in the present study. Troponin-I, troponin-T, creatine kinase (CK), and the MB isoenzyme were measured before operation and postoperatively within 2 days. RESULTS: Postoperative values of troponin-I for children undergoing extracardiac operation were in the normal range. In children with interventions through the right atrium (n = 10) the mean value increase to 6.5+/-6.1 microg/L (range, 1.8 to 24.3 microg/L) and even to a mean of 29.9+/-21.1 microg/L (range, 7.5 to 90 microg/L) (p<0.01) in children with atrial and additional ventricular surgical approach (n = 23). Troponin-I was of equal specificity and sensitivity compared to troponin-T, excepted in patients with postoperative renal failure in whom troponin-T raised to false pathological results. CONCLUSIONS: For detection of perioperative myocardial damage troponin-I shows a higher specificity than CK-MB activity and CK-MB mass. The diagnostic value of troponin-I is similar to troponin-T, but compared with troponin-T, it has the advantage of not being influenced by renal failure.
Authors: Monesha Gupta-Malhotra; Jeffrey H Kern; Patrick A Flynn; Myles S Schiller; Jan M Quaegebeur; Deborah M Friedman Journal: Cardiol Young Date: 2012-07-20 Impact factor: 1.093
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Authors: Emanuela Angeli; Sabrina Martens; Lucio Careddu; Francesco D Petridis; Andrea G Quarti; Cristina Ciuca; Anna Balducci; Assunta Fabozzo; Luca Ragni; Andrea Donti; Gaetano D Gargiulo Journal: Interact Cardiovasc Thorac Surg Date: 2021-01-22