Literature DB >> 9930301

Gene transfer vectors derived from equine infectious anemia virus.

J C Olsen1.   

Abstract

Equine infectious anemia virus (EIAV) is a lentivirus in the retrovirus family of viruses. Replication-defective EIAV vectors have been constructed that encode bacterial puromycin-N-acetyl transferase and E. coli beta-galactosidase. These vectors could be prepared with titers greater than 10(5) infectious units/ml and were able to act as vehicles to carry genes into cultured human cells. In addition, stable helper cell lines were created by modifying human 293 cells to express EIAV proteins. Unlike retroviral vectors based on murine leukemia virus, EIAV lentiviral vectors transduce nondividing (aphidicolin-arrested) cells. These properties make EIAV vectors promising gene transfer vehicles.

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Year:  1998        PMID： 9930301     DOI： 10.1038/sj.gt.3300768

Source DB:  PubMed          Journal:  Gene Ther        ISSN： 0969-7128            Impact factor:   5.250


  65 in total

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