Literature DB >> 9928919

Intravenous self-administration of gamma-hydroxybutyric acid in drug-naive mice.

M C Martellotta1, G Cossu, L Fattore, G L Gessa, W Fratta.   

Abstract

The reinforcing effects of gamma-hydroxybutyric acid (GHB) were studied by means of intravenous self-administration in drug-naive mice. GHB self-administration was concentration-dependent (0.01-0.5 mg/kg/inj.) according to a bell-shaped curve. Pretreatment with the specific GHB receptor antagonist NCS-382 at a dose of 12.5 mg/kg i.p. completely antagonized the reinforcing effects of GHB. These data suggest that GHB is able to induce reinforcing effects in mice and support the hypothesis of an abuse liability of this drug.

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Year:  1998        PMID： 9928919     DOI： 10.1016/s0924-977x(97)00087-4

Source DB:  PubMed          Journal:  Eur Neuropsychopharmacol        ISSN： 0924-977X            Impact factor:   4.600


  9 in total

1.  The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice.

Authors:  Neil E Paterson; Svetlana Semenova; Fabrizio Gasparini; Athina Markou
Journal:  Psychopharmacology (Berl)       Date:  2003-04-08       Impact factor: 4.530

2.  Behavioral effects of gamma-hydroxybutyrate in humans.

Authors:  Alison Oliveto; William Brooks Gentry; Rhonda Pruzinsky; Kishorchandra Gonsai; Thomas R Kosten; Bridget Martell; James Poling
Journal:  Behav Pharmacol       Date:  2010-07       Impact factor: 2.293

3.  Intravenous self-administration of γ-hydroxybutyrate (GHB) in baboons.

Authors:  Amy K Goodwin; Barbara J Kaminski; Roland R Griffiths; Nancy A Ator; Elise M Weerts
Journal:  Drug Alcohol Depend       Date:  2010-11-26       Impact factor: 4.492

4.  Effects of combining ethanol (EtOH) with gamma-hydroxybutyrate (GHB) on the discriminative stimulus, locomotor, and motor-impairing functions of GHB in mice.

Authors:  Charles D Cook; Laura Biddlestone; Andrew Coop; Patrick M Beardsley
Journal:  Psychopharmacology (Berl)       Date:  2006-02-02       Impact factor: 4.530

Review 5.  [Gamma-hydroxybutyrate--a neurotransmitter, medicine, and drug].

Authors:  G Trendelenburg; A Ströhle
Journal:  Nervenarzt       Date:  2005-07       Impact factor: 1.214

6.  α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB).

Authors:  Nathan Absalom; Laura F Eghorn; Inge S Villumsen; Nasiara Karim; Tina Bay; Jesper V Olsen; Gitte M Knudsen; Hans Bräuner-Osborne; Bente Frølund; Rasmus P Clausen; Mary Chebib; Petrine Wellendorph
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-02       Impact factor: 11.205

Review 7.  Behavioral analyses of GHB: receptor mechanisms.

Authors:  Lawrence P Carter; Wouter Koek; Charles P France
Journal:  Pharmacol Ther       Date:  2008-10-29       Impact factor: 12.310

8.  Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration.

Authors:  S Pons; L Fattore; G Cossu; S Tolu; E Porcu; J M McIntosh; J P Changeux; U Maskos; W Fratta
Journal:  J Neurosci       Date:  2008-11-19       Impact factor: 6.167

9.  Improvement in γ-hydroxybutyrate-induced contextual fear memory deficit by systemic administration of NCS-382.

Authors:  Keita Ishiwari; Ratna Sircar
Journal:  Neuroreport       Date:  2016-06-15       Impact factor: 1.837
  9 in total

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