The class of antibody involved in the antibody-dependent cell-mediated lysis of chicken erythrocytes.

Affinity chromatographic experiments demonstrated that IgG was the class of antibody involved in the in vitro lysis of chicken erythrocytes by antibody and normal mouse effector cells. Further experiments designed to investigate the subclass of IgG involved, indicated that IgG2a was active and provided further evidence for the inactivity of IgM, either in the native 19S or chemically degraded 7S form. From the results obtained, the possibility of ADCC-inducing activity in the other IgG subclasses could not be excluded.