J M Suvisaari1, J Haukka, A Tanskanen, J K Lönnqvist. 1. Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland. jaana.suvisaari@kt1.fi
Abstract
BACKGROUND: Recent research suggests that high familial loading is associated with early onset of schizophrenia. Results concerning outcome have been controversial. METHOD: We assessed the relationship between familial loading, age at onset and outcome in all Finnish patients with schizophrenia born between 1950 and 1969. Patients and their first-degree relatives were identified using nationwide registers. Familial loading scores were calculated for schizophrenia and for combined psychotic disorders, and patients were accordingly classified into three groups: high (n = 761), intermediate (n = 14,247), and low familial loading (n = 725). Linear mixed models and the Cox proportional hazard model were used in the analyses. RESULTS: Onset was earliest, hospitalisation longest and risk of retirement in receipt of a disability pension highest in the group with high familial loading, with opposite extremes found in the group with low familial loading. CONCLUSIONS: High familial loading for schizophrenia is associated with early onset and poor outcome of schizophrenia.
BACKGROUND: Recent research suggests that high familial loading is associated with early onset of schizophrenia. Results concerning outcome have been controversial. METHOD: We assessed the relationship between familial loading, age at onset and outcome in all Finnish patients with schizophrenia born between 1950 and 1969. Patients and their first-degree relatives were identified using nationwide registers. Familial loading scores were calculated for schizophrenia and for combined psychotic disorders, and patients were accordingly classified into three groups: high (n = 761), intermediate (n = 14,247), and low familial loading (n = 725). Linear mixed models and the Cox proportional hazard model were used in the analyses. RESULTS: Onset was earliest, hospitalisation longest and risk of retirement in receipt of a disability pension highest in the group with high familial loading, with opposite extremes found in the group with low familial loading. CONCLUSIONS: High familial loading for schizophrenia is associated with early onset and poor outcome of schizophrenia.
Authors: Brian Miller; Jaana Suvisaari; Jouko Miettunen; Marjo-Riitta Järvelin; Jari Haukka; Antti Tanskanen; Jouko Lönnqvist; Matti Isohanni; Brian Kirkpatrick Journal: Schizophr Res Date: 2011-09-19 Impact factor: 4.939
Authors: Lauren V Moran; Grace A Masters; Samira Pingali; Bruce M Cohen; Elizabeth Liebson; R P Rajarethinam; Dost Ongur Journal: J Psychiatr Res Date: 2015-09-21 Impact factor: 4.791