Literature DB >> 9925723

5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist.

S M Bromidge1, A M Brown, S E Clarke, K Dodgson, T Gager, H L Grassam, P M Jeffrey, G F Joiner, F D King, D N Middlemiss, S F Moss, H Newman, G Riley, C Routledge, P Wyman.   

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Year:  1999        PMID： 9925723     DOI： 10.1021/jm980532e

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  24 in total

1.  Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist.

Authors:  C Routledge; S M Bromidge; S F Moss; G W Price; W Hirst; H Newman; G Riley; T Gager; T Stean; N Upton; S E Clarke; A M Brown; D N Middlemiss
Journal:  Br J Pharmacol       Date:  2000-08       Impact factor: 8.739

2.  Dynamics and structural determinants of ligand recognition of the 5-HT6 receptor.

Authors:  Márton Vass; Balázs Jójárt; Ferenc Bogár; Gábor Paragi; György M Keserű; Ákos Tarcsay
Journal:  J Comput Aided Mol Des       Date:  2015-11-16       Impact factor: 3.686

Review 3.  Neurobiological applications of small molecule screening.

Authors:  Andras Bauer; Brent Stockwell
Journal:  Chem Rev       Date:  2008-05-01       Impact factor: 60.622

4.  The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.

Authors:  Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; Michael Spedding; John A Peters; Anthony J Harmar
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

5.  Chronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese rats.

Authors:  Angels Fisas; Xavier Codony; Gonzalo Romero; Alberto Dordal; Jesus Giraldo; Ramon Mercé; Jörg Holenz; N Vrang; R V Sørensen; David Heal; Helmut Buschmann; Petrus Johan Pauwels
Journal:  Br J Pharmacol       Date:  2006-06-19       Impact factor: 8.739

6.  5-HT6/7 receptor antagonists facilitate dopamine release in the cochlea via a GABAergic disinhibitory mechanism.

Authors:  Zoltán Doleviczényi; E Sylvester Vizi; István Gacsályi; Katalin Pallagi; Balázs Volk; László G Hársing; György Halmos; Balázs Lendvai; Tibor Zelles
Journal:  Neurochem Res       Date:  2008-07-29       Impact factor: 3.996

7.  Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies.

Authors:  Małgorzata Dukat; Philip D Mosier; Renata Kolanos; Bryan L Roth; Richard A Glennon
Journal:  J Med Chem       Date:  2008-01-18       Impact factor: 7.446

Review 8.  5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease.

Authors:  Neil Upton; Tsu Tshen Chuang; Ann J Hunter; David J Virley
Journal:  Neurotherapeutics       Date:  2008-07       Impact factor: 7.620

9.  Pro-cognitive effects of 5-HT6 receptor antagonists in the social recognition procedure in rats: implication of the frontal cortex.

Authors:  Florence Loiseau; Anne Dekeyne; Mark J Millan
Journal:  Psychopharmacology (Berl)       Date:  2007-10-06       Impact factor: 4.530

10.  A 5-HT7 heteroreceptor-mediated inhibition of [3H]serotonin release in raphe nuclei slices of the rat: evidence for a serotonergic-glutamatergic interaction.

Authors:  Laszlo G Harsing; Ibolya Prauda; Jozsef Barkoczy; Peter Matyus; Zsolt Juranyi
Journal:  Neurochem Res       Date:  2004-08       Impact factor: 3.996
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