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Literature DB >> 9925553

Italian survey on comparative levofloxacin susceptibility in 334 clinical isolates of Pseudomonas aeruginosa.

B Segatore¹, D Setacci, M Perilli, N Franceschini, A De Santis, F Marchetti, G Amicosante.

Abstract

A national survey on susceptibility patterns of 334 Pseudomonas aeruginosa isolates from intensive care units and hematology and oncology wards from 13 Italian hospitals compared the in vitro activity of levofloxacin, an injectable oral fluoroquinolone, to those of ciprofloxacin, ofloxacin, ceftazidime, imipenem, amikacin, and gentamicin. Amikacin and imipenem had the best susceptibility profiles. The activity of levofloxacin was superior to those of the other quinolones and was comparable to that of ceftazidime. The effect of levofloxacin in vitro on P. aeruginosa clinical isolates suggests that further clinical investigations are warranted.

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Year: 1999 PMID： 9925553 PMCID： PMC89098

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

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Authors: D J Biedenbach; R N Jones
Journal: Diagn Microbiol Infect Dis Date: 1995-01 Impact factor: 2.803

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Authors: L L Shen
Journal: Adv Pharmacol Date: 1994

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Authors: K Hoshino; A Kitamura; I Morrissey; K Sato; J Kato; H Ikeda
Journal: Antimicrob Agents Chemother Date: 1994-11 Impact factor: 5.191

4. Infection problems for the 1990's--do we have an answer?

Authors: H C Neu
Journal: Scand J Infect Dis Suppl Date: 1993

5. Mechanism of differential activities of ofloxacin enantiomers.

Authors: I Morrissey; K Hoshino; K Sato; A Yoshida; I Hayakawa; M G Bures; L L Shen
Journal: Antimicrob Agents Chemother Date: 1996-08 Impact factor: 5.191

6. Activity of 4-quinolones against Pseudomonas aeruginosa.

Authors: I Morissey; J T Smith
Journal: Arzneimittelforschung Date: 1994-10

7. Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacin.

Authors: X Z Li; D M Livermore; H Nikaido
Journal: Antimicrob Agents Chemother Date: 1994-08 Impact factor: 5.191

8. Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to beta-lactam resistance.

Authors: X Z Li; D Ma; D M Livermore; H Nikaido
Journal: Antimicrob Agents Chemother Date: 1994-08 Impact factor: 5.191

4. Levofloxacin and ciprofloxacin in vitro activities against 4,003 clinical bacterial isolates collected in 24 Italian laboratories.

Authors: Giovanni Pietro Gesu; Federico Marchetti; Laura Piccoli; Annalisa Cavallero
Journal: Antimicrob Agents Chemother Date: 2003-02 Impact factor: 5.191

4 in total

Italian survey on comparative levofloxacin susceptibility in 334 clinical isolates of Pseudomonas aeruginosa.

1. Interpretive errors using an automated system for the susceptibility testing of imipenem and aztreonam.

Review 2. Molecular mechanisms of DNA gyrase inhibition by quinolone antibacterials.

3. Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition.

4. Infection problems for the 1990's--do we have an answer?

5. Mechanism of differential activities of ofloxacin enantiomers.

6. Activity of 4-quinolones against Pseudomonas aeruginosa.

7. Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacin.

8. Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to beta-lactam resistance.

Review 9. Levofloxacin. A review of its antibacterial activity, pharmacokinetics and therapeutic efficacy.

10. Levofloxacin in vitro activity: results from an international comparative study with ofloxacin and ciprofloxacin.

1. Bacteriostatic and bactericidal activity of levofloxacin against clinical isolates from cystic fibrosis patients.

Review 2. A critical review of the fluoroquinolones: focus on respiratory infections.

3. Ciprofloxacin susceptibility of Pseudomonas aeruginosa isolates from keratitis.

4. Levofloxacin and ciprofloxacin in vitro activities against 4,003 clinical bacterial isolates collected in 24 Italian laboratories.