Literature DB >> 9925550

In vitro activities of benflumetol against 158 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs.

B Pradines1, A Tall, T Fusai, A Spiegel, R Hienne, C Rogier, J F Trape, J Le Bras, D Parzy.   

Abstract

The 50% inhibitory concentration (IC50s) of benflumetol (range, 12.5 to 240 nM; mean, 55.1 nM) for 158 Senegalese isolates were evaluated. Ten isolates (6%) showed decreased susceptibility to benflumetol. Benflumetol was slightly more potent against chloroquine-resistant isolates (P < 0.025). No correlation or weak correlations in the responses to benflumetol and pyrimethamine, chloroquine, amodiaquine, artemether, quinine, and pyronaridine were observed, and these correlations are insufficient to suggest cross-resistance. Benflumetol may be an important alternative drug for the treatment of chloroquine-resistant malaria.

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Year:  1999        PMID： 9925550      PMCID： PMC89095     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

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Journal:  Parasitol Today       Date:  1986-12

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Journal:  Nature       Date:  1992-01-09       Impact factor: 49.962

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Authors:  B Pradines; C Rogier; T Fusai; A Tall; J F Trape; J C Doury
Journal:  Med Trop (Mars)       Date:  1996

Review 5.  Positioning, labelling, and medical information control of co-artemether tablets (CPG 56697): a fixed novel combination of artemether and benflumetol. Novartis Co-Artemether International Development Team.

Authors:  P Skelton-Stroud; R Mull
Journal:  Med Trop (Mars)       Date:  1998

6.  Correlation between in vivo and in vitro response of chloroquine-resistant Plasmodium falciparum in Calabar, south-eastern Nigeria.

Authors:  A B Umotong; E N Ezedinachi; A A Okerengwo; E A Usanga; J J Udo; A I Williams
Journal:  Acta Trop       Date:  1991-06       Impact factor: 3.112

7.  Indicators of life-threatening malaria in African children.

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Journal:  N Engl J Med       Date:  1995-05-25       Impact factor: 91.245

8.  [Plasmodium falciparum malaria: type R1 quinine resistance in East Africa].

Authors:  S Molinier; P Imbert; D Verrot; M Morillon; D Parzy; J E Touze
Journal:  Presse Med       Date:  1994-10-22       Impact factor: 1.228

9.  Drug sensitivity of Plasmodium falciparum in Gabon. Activity correlations between various antimalarials.

Authors:  S Winkler; C Brandts; W H Wernsdorfer; W Graninger; U Bienzle; P G Kremsner
Journal:  Trop Med Parasitol       Date:  1994-09

10.  Quinine resistant falciparum malaria acquired in east Africa.

Authors:  T Jelinek; P Schelbert; T Löscher; D Eichenlaub
Journal:  Trop Med Parasitol       Date:  1995-03
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  26 in total

1.  Association between the pfmdr1 gene and in vitro artemether and lumefantrine sensitivity in Thai isolates of Plasmodium falciparum.

Authors:  Mathirut Mungthin; Rommanee Khositnithikul; Naruemon Sitthichot; Nantana Suwandittakul; Veerachai Wattanaveeradej; Stephen A Ward; Kesara Na-Bangchang
Journal:  Am J Trop Med Hyg       Date:  2010-11       Impact factor: 2.345

2.  In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax.

Authors:  R N Price; J Marfurt; F Chalfein; E Kenangalem; K A Piera; E Tjitra; N M Anstey; B Russell
Journal:  Antimicrob Agents Chemother       Date:  2010-09-27       Impact factor: 5.191

3.  In Vitro Sensitivity of Pyronaridine in Thai Isolates of Plasmodium falciparum.

Authors:  Kittiya Mahotorn; Peerapan Tan-Ariya; Thunyapit Thita; Toon Ruang-Areerate; Naruemon Sittichot; Nantana Suwandittakul; Mathirut Mungthin
Journal:  Am J Trop Med Hyg       Date:  2018-01-01       Impact factor: 2.345

4.  Prevalence of in vitro resistance to eleven standard or new antimalarial drugs among Plasmodium falciparum isolates from Pointe-Noire, Republic of the Congo.

Authors:  Bruno Pradines; Philippe Hovette; Thierry Fusai; Henri Léonard Atanda; Eric Baret; Philippe Cheval; Joel Mosnier; Alain Callec; Julien Cren; Rémy Amalvict; Jean Pierre Gardair; Christophe Rogier
Journal:  J Clin Microbiol       Date:  2006-07       Impact factor: 5.948

Review 5.  Clinical pharmacokinetics and pharmacodynamics and pharmacodynamics of artemether-lumefantrine.

Authors:  N J White; M van Vugt; F Ezzet
Journal:  Clin Pharmacokinet       Date:  1999-08       Impact factor: 6.447

6.  In vitro sensitivity of Plasmodium falciparum and clinical response to lumefantrine (benflumetol) and artemether.

Authors:  P Tanariya; P Tippawangkoso; J Karbwang; K Na-Bangchang; W H Wernsdorfer
Journal:  Br J Clin Pharmacol       Date:  2000-05       Impact factor: 4.335

7.  Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitro.

Authors:  S T Mariga; J P Gil; C Sisowath; W H Wernsdorfer; A Björkman
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

8.  In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1.

Authors:  Leah Mwai; Steven M Kiara; Abdi Abdirahman; Lewa Pole; Anja Rippert; Abdi Diriye; Pete Bull; Kevin Marsh; Steffen Borrmann; Alexis Nzila
Journal:  Antimicrob Agents Chemother       Date:  2009-09-21       Impact factor: 5.191

Review 9.  Combination therapy for malaria: the way forward?

Authors:  François Nosten; Philippe Brasseur
Journal:  Drugs       Date:  2002       Impact factor: 9.546

10.  In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda.

Authors:  Samuel L Nsobya; Moses Kiggundu; Sarah Nanyunja; Moses Joloba; Bryan Greenhouse; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2010-01-11       Impact factor: 5.191
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