| Literature DB >> 9925536 |
A J De Lucca1, T J Jacks, J Takemoto, B Vinyard, J Peter, E Navarro, T J Walsh.
Abstract
Syringomycin-E (SE) was significantly lethal to Aspergillus and Fusarium species at between 1.9 and 7.8 micrograms/ml. SE complexed with the following fungal wall constituents (in order of binding): beta-1,3-glucan > chitin > mannan > ergosterol = cholesterol. Cytotoxicity in HeLa cells was proportional to the SE concentration, while the amount required for cytotoxicity was 3 to 20 times that needed to kill 95% of the fungi tested.Entities:
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Year: 1999 PMID： 9925536 PMCID： PMC89081
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191