Literature DB >> 9925439

Synthesis and biological evaluation of 2,2-disubstituted 2-aminoethanols: analogues of FTY720.

M Kiuchi1, K Adachi, T Kohara, K Teshima, Y Masubuchi, T Mishina, T Fujita.   

Abstract

Desymmerization of symmetric FTY720 by substitution of different alkyl groups for one of the prochiral hydroxymethyl groups was performed. The size of the alkyl groups and the absolute configuration at quaternary carbon were important on immunosuppressive activity.

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Year:  1998        PMID： 9925439     DOI： 10.1016/s0960-894x(97)10188-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist.

Authors:  Hugh Rosen; Christopher Alfonso; Charles D Surh; Michael G McHeyzer-Williams
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-03       Impact factor: 11.205

2.  The effect of a novel immunosuppressant, FTY720, in mice without secondary lymphoid organs.

Authors:  Kiminobu Sugito; Tsugumichi Koshinaga; Mikiya Inoue; Taro Ikeda; Noritsugu Hagiwara; Masahiro Fukuzawa
Journal:  Surg Today       Date:  2005       Impact factor: 2.549

3.  S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF.

Authors:  Yasuhiro Gon; Malcolm R Wood; William B Kiosses; Euijung Jo; M Germana Sanna; Jerold Chun; Hugh Rosen
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-20       Impact factor: 11.205

4.  Fingolimod: Lessons Learned and New Opportunities for Treating Multiple Sclerosis and Other Disorders.

Authors:  Jerold Chun; Yasuyuki Kihara; Deepa Jonnalagadda; Victoria A Blaho
Journal:  Annu Rev Pharmacol Toxicol       Date:  2019-01-06       Impact factor: 13.820

Review 5.  Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond.

Authors:  Christopher S Garris; Victoria A Blaho; Timothy Hla; May H Han
Journal:  Immunology       Date:  2014-07       Impact factor: 7.397

Review 6.  Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory bowel disease.

Authors:  Bram Verstockt; Stefania Vetrano; Azucena Salas; Shadi Nayeri; Marjolijn Duijvestein; Niels Vande Casteele
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2022-02-14       Impact factor: 73.082

7.  Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza.

Authors:  David Marsolais; Bumsuk Hahm; Kurt H Edelmann; Kevin B Walsh; Miguel Guerrero; Yasuko Hatta; Yoshihiro Kawaoka; Edward Roberts; Michael B A Oldstone; Hugh Rosen
Journal:  Mol Pharmacol       Date:  2008-06-24       Impact factor: 4.436

8.  Effect of FTY720 and ex vivo graft irradiation in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1.

Authors:  Kiminobu Sugito; Mikiya Inoue; Taro Ikeda; Noritsugu Hagiwara; Tsugumichi Koshinaga; Takeshi Kusafuka
Journal:  Surg Today       Date:  2007-12-24       Impact factor: 2.549

9.  Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma.

Authors:  David Gendron; Anne-Marie Lemay; Claudine Tremblay; Laetitia Ja Lai; Anick Langlois; Émilie Bernatchez; Nicolas Flamand; Marie-Renée Blanchet; Anthony S Don; Ynuk Bossé; Élyse Bissonnette; David Marsolais
Journal:  Respir Res       Date:  2015-02-03

10.  FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacology.

Authors:  Kunitomo Adachi; Kenji Chiba
Journal:  Perspect Medicin Chem       Date:  2007-09-06
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