Literature DB >> 9925307

Syntheses and preventive effects of analogues related to 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 (ED-71) on bone mineral loss in ovariectomized rats.

Y Ono1, A Kawase, H Watanabe, A Shiraishi, S Takeda, Y Higuchi, K Sato, T Yamauchi, T Mikami, M Kato, N Tsugawa, T Okano, N Kubodera.   

Abstract

Analogues related to 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 (ED-71) (2), 26,27-dimethyl ED-71 (3) and 26,27-diethyl ED-71 (4), were synthesized from lithocholic acid (5). In the study of the preventive effects of these analogues and ED-71 (2) on bone mineral loss in ovariectomized rats, 26,27-dimethyl ED-71 (3) showed the most potent activity.

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Year:  1998        PMID： 9925307     DOI： 10.1016/s0968-0896(98)80025-4

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  1 in total

1.  Eldecalcitol (ED-71), an analog of 1α,25(OH)2D3, inhibits the growth of squamous cell carcinoma (SCC) cells in vitro and in vivo by down-regulating expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) and FGF-2.

Authors:  T Shintani; F Takatsu; S N Z Rosli; E Usui; A Hamada; K Sumi; Y Hayashido; S Toratani; Tetsuji Okamoto
Journal:  In Vitro Cell Dev Biol Anim       Date:  2017-07-14       Impact factor: 2.416
  1 in total

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