Literature DB >> 9925299

The design, synthesis, and evaluation of novel conformationally rigid analogues of sialyl Lewis(x).

P V Murphy1, R E Hubbard, D T Manallack, R E Wills, J G Montana, R J Taylor.   

Abstract

The design and synthesis of a series of analogues of sialyl Lewis(x)(1) which incorporate conformationally rigid tetralin and naphthalene ring systems(2-4) has led to novel compounds which have similar potency to 1 as inhibitors of cell adhesion.

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Year:  1998        PMID: 9925299     DOI: 10.1016/s0968-0896(98)80017-5

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN: 0968-0896            Impact factor:   3.641


  1 in total

1.  Mirror-image carbohydrates: synthesis of the unnatural enantiomer of a blood group trisaccharide.

Authors:  Fabien P Boulineau; Alexander Wei
Journal:  J Org Chem       Date:  2004-05-14       Impact factor: 4.354

  1 in total

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