| Literature DB >> 9925286 |
J J Fernández1, M L Souto, M Norte.
Abstract
In this paper, we report on the conformational analysis of several polyether triterpenes with a squalene carbon skeleton which exhibited significant cytotoxic activity using a Monte Carlo conformational search and spectroscopical data. These studies indicate that the conformation of the side chain C-14/C-19 and the arrangement and direction of this chain may be among the fundamental factors related to the activity of this type of metabolites.Entities:
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Year: 1998 PMID： 9925286 DOI： 10.1016/s0968-0896(98)80004-7
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641