BACKGROUND: Leptin is known to be cleared by the kidney, a tissue with substantial leptin receptor mRNA expression; however, lung, liver, and muscle tissues also express leptin receptor messenger RNA and it is not known whether these tissues also clear leptin from the circulation. OBJECTIVE: This study was conducted to determine whether net leptin clearance takes place in the pulmonary, splanchnic, and leg tissue beds to a similar extent as in the kidney. DESIGN: Plasma leptin concentrations were measured in blood entering and exiting the renal bed, pulmonary bed, splanchnic bed, and leg in 4 groups of subjects. Regional plasma flow was measured in 3 of the 4 groups. RESULTS: Renal leptin uptake was substantial, whereas no net uptake of leptin by the splanchnic or pulmonary vascular beds was detected; leg tissue was a net leptin producer. Net leptin release by leg tissue, relative to leg adipose tissue mass, was comparable with that reported previously for abdominal subcutaneous adipose tissue. CONCLUSION: These results confirm that the kidney is a significant site of leptin clearance in humans, whereas pulmonary and splanchnic beds are not.
BACKGROUND:Leptin is known to be cleared by the kidney, a tissue with substantial leptin receptor mRNA expression; however, lung, liver, and muscle tissues also express leptin receptor messenger RNA and it is not known whether these tissues also clear leptin from the circulation. OBJECTIVE: This study was conducted to determine whether net leptin clearance takes place in the pulmonary, splanchnic, and leg tissue beds to a similar extent as in the kidney. DESIGN: Plasma leptin concentrations were measured in blood entering and exiting the renal bed, pulmonary bed, splanchnic bed, and leg in 4 groups of subjects. Regional plasma flow was measured in 3 of the 4 groups. RESULTS: Renal leptin uptake was substantial, whereas no net uptake of leptin by the splanchnic or pulmonary vascular beds was detected; leg tissue was a net leptin producer. Net leptin release by leg tissue, relative to leg adipose tissue mass, was comparable with that reported previously for abdominal subcutaneous adipose tissue. CONCLUSION: These results confirm that the kidney is a significant site of leptin clearance in humans, whereas pulmonary and splanchnic beds are not.
Authors: Søren Gregersen; Janus L Thomsen; Per B Jeppesen; Kirsten K Alstrup; Birgitte Brock; Steen B Pedersen; Kurt Kristensen; Kjeld Hermansen Journal: Lipids Date: 2003-05 Impact factor: 1.880
Authors: Dafne Pérez-Montarelo; Almudena Fernández; Carmen Barragán; Jose L Noguera; Josep M Folch; M Carmen Rodríguez; Cristina Ovilo; Luis Silió; Ana I Fernández Journal: PLoS One Date: 2013-06-18 Impact factor: 3.240
Authors: Ahmed Nabih El-Shazly; Soha Abd El-Hady Ibrahim; Ghada Mohamed El-Mashad; Jehan H Sabry; Nashwa Said Sherbini Journal: Int J Nephrol Renovasc Dis Date: 2015-12-10