BACKGROUND: Cutaneous malignancy is a major cause of morbidity in organ transplant recipients. OBJECTIVE: Our purpose was to report on skin cancer in Australian heart transplant recipients with analysis of HLA factors. METHODS: We reviewed histologically proven skin cancers in the first 455 patients undergoing organ transplantation in Sydney, Australia. RESULTS: The cumulative incidence of skin cancer was 31% at 5 years and 43% at 10 years with a squamous cell carcinoma/basal cell carcinoma ratio of 3:1. Caucasian origin, increasing age at transplantation, and duration of follow-up were significantly associated with skin cancer. Skin cancer accounted for 27% of 41 deaths occurring after the fourth year. Recipient HLA-DR homozygosity was associated with skin cancer overall, whereas HLA-DR7 was a protective factor in skin cancer overall, squamous cell carcinoma, and Bowen's disease. HLA-A1 and HLA-A11 were significant protective factors in Bowen's disease. CONCLUSION: Skin cancer is a major cause of morbidity and long-term mortality in heart transplant patients.
BACKGROUND:Cutaneous malignancy is a major cause of morbidity in organ transplant recipients. OBJECTIVE: Our purpose was to report on skin cancer in Australian heart transplant recipients with analysis of HLA factors. METHODS: We reviewed histologically proven skin cancers in the first 455 patients undergoing organ transplantation in Sydney, Australia. RESULTS: The cumulative incidence of skin cancer was 31% at 5 years and 43% at 10 years with a squamous cell carcinoma/basal cell carcinoma ratio of 3:1. Caucasian origin, increasing age at transplantation, and duration of follow-up were significantly associated with skin cancer. Skin cancer accounted for 27% of 41 deaths occurring after the fourth year. Recipient HLA-DR homozygosity was associated with skin cancer overall, whereas HLA-DR7 was a protective factor in skin cancer overall, squamous cell carcinoma, and Bowen's disease. HLA-A1 and HLA-A11 were significant protective factors in Bowen's disease. CONCLUSION:Skin cancer is a major cause of morbidity and long-term mortality in heart transplant patients.
Authors: M Mansh; M Binstock; K Williams; F Hafeez; J Kim; D Glidden; R Boettger; S Hays; J Kukreja; J Golden; M M Asgari; P Chin-Hong; J P Singer; S T Arron Journal: Am J Transplant Date: 2015-09-03 Impact factor: 8.086
Authors: Christopher Metchnikoff; Thaddeus Mully; Jonathan P Singer; Jeffrey A Golden; Sarah T Arron Journal: J Am Acad Dermatol Date: 2012-01-29 Impact factor: 11.527
Authors: Peter Hyckel; Peter Schleier; Astrid Meerbach; Alexander Berndt; Hartwig Kosmehl; Peter Wutzler Journal: Med Microbiol Immunol Date: 2003-04-10 Impact factor: 3.402
Authors: Jerry D Brewer; Oscar R Colegio; P Kim Phillips; Randall K Roenigk; M Amanda Jacobs; Diederik Van de Beek; Ross A Dierkhising; Walter K Kremers; Christopher G A McGregor; Clark C Otley Journal: Arch Dermatol Date: 2009-12