Literature DB >> 9921577

Sequence comparison of outer membrane phospholipases A: implications for structure and for the catalytic mechanism.

R G Brok1, A P Boots, N Dekker, H M Verheij, J Tommassen.   

Abstract

In this study, the nucleotide sequence of the Enterobacter agglomerans pldA gene encoding outer membrane phospholipase A (OMPLA; EC 3.1.1.32) was determined. Five other OMPLA amino acid sequences have previously been described, and screening of data bases of whole genome sequencing projects revealed the presence of proteins with homology to OMPLA in Helicobacter pylori, Campylobacter jejuni, Yersinia pestis, Neisseria menigitidis and Neisseria gonorrhoeae. Comparison of these eleven OMPLA amino acid sequences revealed that 30 amino acid residues are completely conserved. Implications of the sequence comparison for the catalytic mechanism of OMPLA are discussed. The presence of proteins homologous to OMPLA even in non-enterobacterial Gram-negative bacteria indicates an important physiological role of this enzyme.

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Year:  1998        PMID： 9921577     DOI： 10.1016/s0923-2508(99)80017-5

Source DB:  PubMed          Journal:  Res Microbiol        ISSN： 0923-2508            Impact factor:   3.992


  6 in total

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Journal:  Mol Microbiol       Date:  2014-06-18       Impact factor: 3.501

2.  Function of neisserial outer membrane phospholipase a in autolysis and assessment of its vaccine potential.

Authors:  Martine P Bos; Boris Tefsen; Pierre Voet; Vincent Weynants; Jos P M van Putten; Jan Tommassen
Journal:  Infect Immun       Date:  2005-04       Impact factor: 3.441

3.  Application of high-density array-based signature-tagged mutagenesis to discover novel Yersinia virulence-associated genes.

Authors:  A V Karlyshev; P C Oyston; K Williams; G C Clark; R W Titball; E A Winzeler; B W Wren
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

4.  Phase variation in the Helicobacter pylori phospholipase A gene and its role in acid adaptation.

Authors:  T Tannaes; N Dekker; G Bukholm; J J Bijlsma; B J Appelmelk
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

5.  Campylobacter jejuni permeabilizes the host cell membrane by short chain lysophosphatidylethanolamines.

Authors:  Xuefeng Cao; Chris H A van de Lest; Liane Z X Huang; Jos P M van Putten; Marc M S M Wösten
Journal:  Gut Microbes       Date:  2022 Jan-Dec

6.  In silico evolutionary analysis of Helicobacter pylori outer membrane phospholipase A (OMPLA).

Authors:  Hilde S Vollan; Tone Tannaes; Yoshio Yamaoka; Geir Bukholm
Journal:  BMC Microbiol       Date:  2012-09-13       Impact factor: 3.605
  6 in total

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