| Literature DB >> 9920493 |
K Cristina de Oliveira1, R M Gonçalves de Andrade, A L Giusti, W Dias da Silva, D V Tambourgi.
Abstract
In order to investigate intraspecific differences in Loxosceles intermedia spider venom we compared some biological properties of male and female venoms. Females produced higher amounts of venom than males. Furthermore, female venom presented more potent dermonecrotic and complement-dependent activities than male venom. Interestingly, the F35 toxin, a dermonecrotic and complement-dependent haemolytic factor, was also present in greater amounts in female venom, as demonstrated by ELISA. Therefore, the higher production and increased toxicity of venom in female specimens as compared to males may contribute to the variability observed in the severity of envenoming caused by L. intermedia spiders.Entities:
Mesh：
Substances：
Year: 1999 PMID： 9920493 DOI： 10.1016/s0041-0101(98)00130-5
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033