Literature DB >> 9920131

Time-course of infection and responses in a coughing rat model of pertussis.

Elizabeth Hall, R Parton, A C Wardlaw.   

Abstract

Adult female Sprague-Dawley rats were challenged intrabronchially with Bordetella pertussis strain 18-323 embedded in fine agarose beads and the time-course of infection and other events was determined. There was a steady decline in the numbers of B. pertussis recovered from the rat lungs, with clearance of the infection in most animals by day 12. Leucocytosis, lung inflammation and an increase in total serum IgE in the rats as a result of the challenge were highest around day 10, which was coincident with the highest incidence of coughing in such animals. IgG and IgA antibodies to the B. pertussis antigens pertussis toxin and filamentous haemagglutinin were not detected until after this period. The coughing rat model of pertussis resembles the human disease in the relationship between the time course of infection and cough production.

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Year:  1999        PMID： 9920131     DOI： 10.1099/00222615-48-1-95

Source DB:  PubMed          Journal:  J Med Microbiol        ISSN： 0022-2615            Impact factor:   2.472


  7 in total

1.  The Mechanism of Pertussis Cough Revealed by the Mouse-Coughing Model.

Authors:  Yukihiro Hiramatsu; Koichiro Suzuki; Takashi Nishida; Naoki Onoda; Takashi Satoh; Shizuo Akira; Masahito Ikawa; Hiroko Ikeda; Junzo Kamei; Sandra Derouiche; Makoto Tominaga; Yasuhiko Horiguchi
Journal:  mBio       Date:  2022-03-31       Impact factor: 7.786

2.  BspR/BtrA, an Anti-σ Factor, Regulates the Ability of Bordetella bronchiseptica To Cause Cough in Rats.

Authors:  Keiji Nakamura; Noriko Shinoda; Yukihiro Hiramatsu; Shinya Ohnishi; Shigeki Kamitani; Yoshitoshi Ogura; Tetsuya Hayashi; Yasuhiko Horiguchi
Journal:  mSphere       Date:  2019-04-24       Impact factor: 4.389

3.  Tick-borne zoonotic agents infecting horses from an urban area in Midwestern Brazil: epidemiological and hematological features.

Authors:  João Bosco Vilela Campos; Filipe Santos Martins; Carina Elisei de Oliveira; Amanda Alves Taveira; João Roberto de Oliveira; Luiz Ricardo Gonçalves; Matheus Dias Cordeiro; Ana Claudia Calchi; Lina de Campos Binder; Maria Carolina de Azevedo Serpa; Amália Regina Mar Barbieri; Marcelo B Labruna; Rosangela Zacarias Machado; Gisele Braziliano de Andrade; Marcos Rogério André; Heitor Miraglia Herrera
Journal:  Trop Anim Health Prod       Date:  2021-09-22       Impact factor: 1.559

4.  Mucosal Immunization with DTaP Confers Protection against Bordetella pertussis Infection and Cough in Sprague-Dawley Rats.

Authors:  Jesse M Hall; Graham J Bitzer; Megan A DeJong; Jason Kang; Ting Y Wong; M Allison Wolf; Justin R Bevere; Mariette Barbier; F Heath Damron
Journal:  Infect Immun       Date:  2021-09-13       Impact factor: 3.441

5.  The Fim and FhaB adhesins play a crucial role in nasal cavity infection and Bordetella pertussis transmission in a novel mouse catarrhal infection model.

Authors:  Jana Holubova; Ondrej Stanek; Attila Juhasz; Illiassou Hamidou Soumana; Peter Makovicky; Peter Sebo
Journal:  PLoS Pathog       Date:  2022-04-08       Impact factor: 6.823

Review 6.  Non-primate animal models for pertussis: back to the drawing board?

Authors:  Nevio Cimolai
Journal:  Appl Microbiol Biotechnol       Date:  2022-02-01       Impact factor: 4.813

7.  Reinvestigating the Coughing Rat Model of Pertussis To Understand Bordetella pertussis Pathogenesis.

Authors:  Jesse M Hall; Jason Kang; Sophia M Kenney; Ting Y Wong; Graham J Bitzer; Claire O Kelly; Caleb A Kisamore; Dylan T Boehm; Megan A DeJong; M Allison Wolf; Emel Sen-Kilic; Alexander M Horspool; Justin R Bevere; Mariette Barbier; F Heath Damron
Journal:  Infect Immun       Date:  2021-06-14       Impact factor: 3.441
  7 in total

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