Literature DB >> 991994

Early investigations on the effect of methyl mercuric chloride upon DMN-acute hepatotoxicity.

P Pani, A Sanna, M I Brigaglia, A Columbano, L Congiu.   

Abstract

Acute toxicity induced by DMN was partially prevented by previously administering methyl mercuric chloride (MMC), a chemical inhibitor of the drug metabolizing enzyme system (DMES). We have studied the early changes occurring during the course of DMN-intoxication, namely disaggregation of polysomal profiles and necrosis, evaluated morphologically and by the release of S-GPT.

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Year:  1976        PMID： 991994     DOI： 10.1007/bf01937427

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  14 in total

1.  Repression of dimethylnitrosamine-demethylase by typical inducers of microsomal mixed-function oxidases.

Authors:  J C Arcos; G M Bryant; N Venkatesan; M F Argus
Journal:  Biochem Pharmacol       Date:  1975-08-15       Impact factor: 5.858

2.  Differential effect of polycyclic hydrocarbons on the demethylation of the carcinogen dimethylnitrosamine by rat tissues.

Authors:  N Venkatesan; J C Arcos; M F Argus
Journal:  Life Sci       Date:  1968-10-01       Impact factor: 5.037

3.  The use of new methods to measure: the effect of diet and inducers of microsomal enzyme synthesis on cytochrome P-450 in liver homogenates, and on metabolism of dimethyl nitrosamine.

Authors:  A E McLean; P A Day
Journal:  Biochem Pharmacol       Date:  1974-04-01       Impact factor: 5.858

4.  Decreased toxicity of dimethylnitrosamine in rats after treatment with carbon tetrachloride.

Authors:  A W Pound; L Horn; T A Lawson
Journal:  Pathology       Date:  1973-07       Impact factor: 5.306

Review 5.  Carbon tetrachloride hepatotoxicity.

Authors:  R O Recknagel
Journal:  Pharmacol Rev       Date:  1967-06       Impact factor: 25.468

Review 6.  Carcinogenic nitroso compounds.

Authors:  P N Magee; J M Barnes
Journal:  Adv Cancer Res       Date:  1967       Impact factor: 6.242

7.  Effect of methylmercury hydroxide on rat liver microsomal enzymes.

Authors:  G Lucier; O McDaniel; P Brubaker; R Klein
Journal:  Chem Biol Interact       Date:  1972-03       Impact factor: 5.192

8.  Protection by lead nitrate against carbon tetrachloride hepatotoxicity.

Authors:  P Pani; F P Corongiu; A Sanna; L Congiu
Journal:  Drug Metab Dispos       Date:  1975 May-Jun       Impact factor: 3.922

9.  Protection against carbon tetrachloride-induced hepatotoxicity by pretreatment with methylmercury hydroxide.

Authors:  G P Carlson
Journal:  Toxicology       Date:  1975       Impact factor: 4.221

10.  Increased carcinogenic action of dimethylnitrosamine after prior administration of carbon tetrachloride.

Authors:  A W Pound; T A Lawson; L Horn
Journal:  Br J Cancer       Date:  1973-06       Impact factor: 7.640
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