Literature DB >> 991934

Anticholinergic and cardiodepressive effects of levomepromazine and two of its metabolites on isolated rat atria.

M Passwal, S G Dahl, H Refsum.   

Abstract

The effects of monodesmethyl levomepromazine on effective refractory period (ERP) threshold for electrical stimulation and contractile force on isolated rat atria were compared to the effects of levomepromazine and levomepromazine sulfoxide. All agents caused an apparently dose-dependent increase in ERP, and antagonized acetylcholine-induced reductions in ERP. Levomepromazine and monodesmethyl levomepromazine decreased excitability and contractile force to a similar extent.

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Year:  1976        PMID： 991934     DOI： 10.1016/0014-2999(76)90059-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  3 in total

1.  Binding affinity of levomepromazine and two of its major metabolites of central dopamine and alpha-adrenergic receptors in the rat.

Authors:  S G Dahl; H Hall
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

2.  Metabolism of levomepromazine in man.

Authors:  P A Hals; S G Dahl
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1995 Jan-Mar       Impact factor: 2.441

3.  Presence of chlorprothixene and its metabolites in breast milk.

Authors:  I Matheson; A Evang; K F Overø; G Syversen
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953
  3 in total

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