Literature DB >> 991829

Decreased pancreatic somatostatin (SRIF) concentration in spontaneously diabetic mice.

Y C Patel, L Orci, A Bankier, D P Cameron.   

Abstract

Spontaneously diabetic C57BL/6J obob and C57BL/Ks dbdb mice have been shown to have significantly decreased immunoassayable pancreatic somatostatin concentrations compared to lean littermate controls at 11-12 weeks: obob 1.06+/-0.15 pg/mug protein (n=10) vs control 1.94+/-0.-6 pg/mug protein (n=10) (mean +/- SE; p less than 0.005); dbdb 0.7+/-0.2 pg/mug protein (n=8) vs control 1.5+/-0.2 pg/mug protein (n=8) (mean +/- SE; p less than 0.005). An inverse relationship between circulating insulin levels and pancreatic SRIF concentration is suggested.

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Year:  1976        PMID： 991829     DOI： 10.1210/endo-99-5-1415

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  9 in total

1.  The rate of degradation of liver glycogen phosphorylase is specifically decreased in the C57BL/KsJ-db/db mouse.

Authors:  W J Roesler; M S Nijjar; R L Khandelwal
Journal:  Mol Cell Biochem       Date:  1989-06-01       Impact factor: 3.396

Review 2.  The milieu interieur and the islets of Langerhans.

Authors:  R H Unger
Journal:  Diabetologia       Date:  1981       Impact factor: 10.122

3.  The effect of short-term intravenous insulin administration on the glucagon response to a carbohydrate meal in adult onset and juvenile type diabetes.

Authors:  I Aydin; P Raskin; R H Unger
Journal:  Diabetologia       Date:  1977-12       Impact factor: 10.122

4.  Somatostatin-like immunoreactivity in rat blood. Characterization, regional differences, and responses to oral and intravenous glucose.

Authors:  M Berelowitz; S Kronheim; B Pimstone; B Shapiro
Journal:  J Clin Invest       Date:  1978-05       Impact factor: 14.808

5.  Fine structural studies of the islets of langerhans in the Djungarian hamster (Phodopus sungorus).

Authors:  K M Voss; L Herberg; H F Kern
Journal:  Cell Tissue Res       Date:  1978-07-27       Impact factor: 5.249

6.  Pancreatic immunoreactive somatostatin and diabetes mellitus.

Authors:  A Ertan; A Arimura; K Akdamar; T Shibata; K Groot; M Luciano; F J Mather; H Degertekin; N Agrawal; J Ryan
Journal:  Dig Dis Sci       Date:  1984-07       Impact factor: 3.199

7.  Quantitative electron-microscopic studies of langerhans islets in normoglycemic chinese hamsters of a diabetic strain.

Authors:  V Meister; G L Rossi
Journal:  Acta Diabetol Lat       Date:  1978 Jan-Apr

8.  Somatostatin in the pancreas and hypothalamus of obese mice.

Authors:  J Dolais-Kitabgi; Y Le Marchand-Brustel; P Freychet
Journal:  Diabetologia       Date:  1979-10       Impact factor: 10.122

9.  Adequate connexin-mediated coupling is required for proper insulin production.

Authors:  C Vozzi; S Ullrich; A Charollais; J Philippe; L Orci; P Meda
Journal:  J Cell Biol       Date:  1995-12       Impact factor: 10.539
  9 in total

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