Literature DB >> 9917624

Pathophysiology of delayed healing.

R A Hayda1, C T Brighton, J L Esterhai.   

Abstract

Delayed union represents an ongoing failure of initial fracture management. It still occurs partly because the precise reason why a patient's fracture does not heal frequently is unknown. This article aims to outline the limited material available on the pathophysiology of delayed healing. The systemic status of the patient, local limb status before injury, the nature of the traumatic injury, local host response to the injury, potential negative impact of orthopaedic fracture care, and pharmacologic variables are considered.

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Year:  1998        PMID： 9917624     DOI： 10.1097/00003086-199810001-00005

Source DB:  PubMed          Journal:  Clin Orthop Relat Res        ISSN： 0009-921X            Impact factor:   4.176


  17 in total

1.  [Platelet-rich plasma combined with autologous cancellous bone : An alternative therapy for persistent non-union?].

Authors:  M Hakimi; P Jungbluth; S Thelen; M Betsch; W Linhart; S Flohé; J Windolf; M Wild
Journal:  Unfallchirurg       Date:  2011-11       Impact factor: 1.000

2.  [Osteoblasts : cellular and molecular regulatory mechanisms in fracture healing].

Authors:  A Hofmann; S G Mattyasovszky; C Brüning; U Ritz; I Mehling; A Meurer; P M Rommens
Journal:  Orthopade       Date:  2009-11       Impact factor: 1.087

3.  [Results of nonunion treatment with bone morphogenetic protein 7 (BMP-7)].

Authors:  A Moghaddam-Alvandi; G Zimmermann; A Büchler; C Elleser; B Biglari; P A Grützner; C G Wölfl
Journal:  Unfallchirurg       Date:  2012-06       Impact factor: 1.000

4.  [Clinical experience with bone morphogenetic protein 7 (BMP 7) in nonunions of long bones].

Authors:  G Zimmermann; A Moghaddam; C Wagner; B Vock; A Wentzensen
Journal:  Unfallchirurg       Date:  2006-07       Impact factor: 1.000

Review 5.  Fracture healing under healthy and inflammatory conditions.

Authors:  Lutz Claes; Stefan Recknagel; Anita Ignatius
Journal:  Nat Rev Rheumatol       Date:  2012-01-31       Impact factor: 20.543

6.  Mesenchymal stem cells facilitate fracture repair in an alcohol-induced impaired healing model.

Authors:  Thomas S Obermeyer; David Yonick; Kristen Lauing; Stuart R Stock; Rachel Nauer; Patrick Strotman; Ravi Shankar; Richard Gamelli; Michael Stover; John J Callaci
Journal:  J Orthop Trauma       Date:  2012-12       Impact factor: 2.512

Review 7.  Effects of anti-osteoporosis medications on fracture healing.

Authors:  Niklas R Jørgensen; Peter Schwarz
Journal:  Curr Osteoporos Rep       Date:  2011-09       Impact factor: 5.096

8.  Altered relative expression of BMPs and BMP inhibitors in cartilaginous areas of human fractures progressing towards nonunion.

Authors:  Francois N K Kwong; Judith A Hoyland; Anthony J Freemont; Christopher H Evans
Journal:  J Orthop Res       Date:  2009-06       Impact factor: 3.494

9.  A role for gamma/delta T cells in a mouse model of fracture healing.

Authors:  Nona T Colburn; Kristien J M Zaal; Francis Wang; Rocky S Tuan
Journal:  Arthritis Rheum       Date:  2009-06

Review 10.  Mesenchymal stem cells for bone repair and metabolic bone diseases.

Authors:  Anita H Undale; Jennifer J Westendorf; Michael J Yaszemski; Sundeep Khosla
Journal:  Mayo Clin Proc       Date:  2009-10       Impact factor: 7.616
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