Literature DB >> 9917290

Novel anti-HIV lancilactone C and related triterpenes from Kadsura lancilimba.

D F Chen1, S X Zhang, H K Wang, S Y Zhang, Q Z Sun, L M Cosentino, K H Lee.   

Abstract

Three new triterpene lactones, lancilactones A (1), B (2), and C (3), together with the known kadsulactone A (4), were isolated from the stems and roots of Kadsura lancilimba. Their structures and stereochemistries were determined primarily from mass and NMR spectral data. Compound 3 inhibited HIV replication with an EC50 value of 1.4 microg/mL and a therapeutic index of greater than 71.4.

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Year:  1999        PMID： 9917290     DOI： 10.1021/np980291d

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

1.  Anti-RAFLS Triterpenoids and Hepatoprotective Lignans From the Leaves of Tujia Ethnomedicine Kadsura heteroclita (Xuetong).

Authors:  Mengyun Wang; Sai Jiang; Nusrat Hussain; Salman Zafar; Qingling Xie; Feibing Huang; Linxi Mao; Bin Li; Yuqing Jian; Wei Wang
Journal:  Front Chem       Date:  2022-05-10       Impact factor: 5.545

2.  Isolation, Structural Elucidation of Three New Triterpenoids from the Stems and Leaves of Schisandra chinensis (Turcz) Baill.

Authors:  Feng Qiu; Han Liu; Huan Duan; Pian Chen; Shao-Juan Lu; Guang-Zhong Yang; Xin-Xiang Lei
Journal:  Molecules       Date:  2018-07-04       Impact factor: 4.411

Review 3.  The potential of plant systems to break the HIV-TB link.

Authors:  Peyman Habibi; Henry Daniell; Carlos Ricardo Soccol; Maria Fatima Grossi-de-Sa
Journal:  Plant Biotechnol J       Date:  2019-07-18       Impact factor: 9.803

Review 4.  Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products.

Authors:  Ramandeep Kaur; Pooja Sharma; Girish K Gupta; Fidele Ntie-Kang; Dinesh Kumar
Journal:  Molecules       Date:  2020-04-29       Impact factor: 4.411

Review 5.  Emerging paradigms of viral diseases and paramount role of natural resources as antiviral agents.

Authors:  R Sagaya Jansi; Ameer Khusro; Paul Agastian; Ahmed Alfarhan; Naif Abdullah Al-Dhabi; Mariadhas Valan Arasu; Rajakrishnan Rajagopal; Damia Barcelo; Amal Al-Tamimi
Journal:  Sci Total Environ       Date:  2020-11-07       Impact factor: 7.963

6.  Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug Candidate.

Authors:  Raya Soltane; Amani Chrouda; Ahmed Mostafa; Ahmed A Al-Karmalawy; Karim Chouaïb; Abdelwaheb Dhahri; Rami Adel Pashameah; Ahlam Alasiri; Omnia Kutkat; Mahmoud Shehata; Hichem Ben Jannet; Jawhar Gharbi; Mohamed A Ali
Journal:  Pathogens       Date:  2021-05-19

Review 7.  Natural Products as Anti-HIV Agents and Role in HIV-Associated Neurocognitive Disorders (HAND): A Brief Overview.

Authors:  Kesava Rao V Kurapati; Venkata S Atluri; Thangavel Samikkannu; Gabriella Garcia; Madhavan P N Nair
Journal:  Front Microbiol       Date:  2016-01-12       Impact factor: 5.640
  7 in total

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