Literature DB >> 9917006

A new anti-MRSA antibiotic complex, WAP-8294A. I. Taxonomy, isolation and biological activities.

A Kato1, S Nakaya, N Kokubo, Y Aiba, Y Ohashi, H Hirata, K Fujii, K Harada.   

Abstract

WAP-8294A, produced by Lysobacter sp., is a complex consisting of water soluble depsipeptide antibiotics. It was further purified by column chromatographies and HPLC, and 19 components were obtained. WAP-8294A2, a major component, and minor components A1, A4, Ax8, Ax9 and Ax13 were active against gram-positive bacteria, in particular, methicillin-resistant Staphylococcus aureus (MRSA) in vitro. WAP-8294A2 was highly active in vivo in mice against the systemic infection of MRSA.

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Year:  1998        PMID： 9917006     DOI： 10.7164/antibiotics.51.929

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  15 in total

1.  Identification and characterization of the anti-methicillin-resistant Staphylococcus aureus WAP-8294A2 biosynthetic gene cluster from Lysobacter enzymogenes OH11.

Authors:  Wei Zhang; Yaoyao Li; Guoliang Qian; Yan Wang; Haotong Chen; Yue-Zhong Li; Fengquan Liu; Yuemao Shen; Liangcheng Du
Journal:  Antimicrob Agents Chemother       Date:  2011-09-19       Impact factor: 5.191

2.  Evidence of an Unidentified Extracellular Heat-Stable Factor Produced by Lysobacter enzymogenes (OH11) that Degrade Fusarium graminearum PH1 Hyphae.

Authors:  Benard Omondi Odhiambo; Gaoge Xu; Guoliang Qian; Fengquan Liu
Journal:  Curr Microbiol       Date:  2017-02-17       Impact factor: 2.188

3.  Yield Improvement of the Anti-MRSA Antibiotics WAP-8294A by CRISPR/dCas9 Combined with Refactoring Self-Protection Genes in Lysobacter enzymogenes OH11.

Authors:  Lingjun Yu; Wei Su; Paul D Fey; Fengquan Liu; Liangcheng Du
Journal:  ACS Synth Biol       Date:  2017-11-20       Impact factor: 5.110

Review 4.  Bioactive natural products from Lysobacter.

Authors:  Yunxuan Xie; Stephen Wright; Yuemao Shen; Liangcheng Du
Journal:  Nat Prod Rep       Date:  2012-11       Impact factor: 13.423

Review 5.  Advances in MRSA drug discovery: where are we and where do we need to be?

Authors:  Michio Kurosu; Shajila Siricilla; Katsuhiko Mitachi
Journal:  Expert Opin Drug Discov       Date:  2013-07-06       Impact factor: 6.098

Review 6.  Host defense antimicrobial peptides as antibiotics: design and application strategies.

Authors:  Biswajit Mishra; Scott Reiling; D Zarena; Guangshun Wang
Journal:  Curr Opin Chem Biol       Date:  2017-04-08       Impact factor: 8.822

7.  Facile method for site-specific gene integration in Lysobacter enzymogenes for yield improvement of the anti-MRSA antibiotics WAP-8294A and the antifungal antibiotic HSAF.

Authors:  Yan Wang; Guoliang Qian; Fengquan Liu; Yue-Zhong Li; Yuemao Shen; Liangcheng Du
Journal:  ACS Synth Biol       Date:  2013-08-27       Impact factor: 5.110

8.  Microbial communities associated with the larval gut and eggs of the Western corn rootworm.

Authors:  Flavia Dematheis; Benedikt Kurtz; Stefan Vidal; Kornelia Smalla
Journal:  PLoS One       Date:  2012-10-02       Impact factor: 3.240

9.  Biosynthetic mechanism for sunscreens of the biocontrol agent Lysobacter enzymogenes.

Authors:  Yan Wang; Guoliang Qian; Yaoyao Li; Yansheng Wang; Yulan Wang; Stephen Wright; Yuezhong Li; Yuemao Shen; Fengquan Liu; Liangcheng Du
Journal:  PLoS One       Date:  2013-06-24       Impact factor: 3.240

10.  Hfq regulates antibacterial antibiotic biosynthesis and extracellular lytic-enzyme production in Lysobacter enzymogenes OH11.

Authors:  Gaoge Xu; Yuxin Zhao; Liangcheng Du; Guoliang Qian; Fengquan Liu
Journal:  Microb Biotechnol       Date:  2015-02-13       Impact factor: 5.813
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