| Literature DB >> 9916124 |
Abstract
Antisera generated against each of the nine known chemotypes of Salmonella lipopolysaccharide (LPS) core were characterized in order to delineate cross-reactive epitopes and define the bases for their accessibility. Strongly cross-reactive epitopes were associated with three chemotypes: Ra and Rb4, which recognized alpha-GlcNAc-1-->2-alpha-Glc, and Rd1, which recognized L-alpha-D-heptose-1-->7-L-alpha-D-heptose. Both these disaccharides and the more weakly cross-reactive alpha-Gal-1-->6-alpha-Glc terminal in Rb3 LPS represent branch points along the core oligosaccharide. Therefore, branch points in endotoxin core oligosaccharides may generally be cross-reactive.Entities:
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Year: 1999 PMID: 9916124 PMCID: PMC96420
Source DB: PubMed Journal: Infect Immun ISSN: 0019-9567 Impact factor: 3.441