Literature DB >> 9916118

Pseudomonas aeruginosa keratitis in knockout mice deficient in intercellular adhesion molecule 1.

J A Hobden1, S Masinick-McClellan, R P Barrett, K S Bark, L D Hazlett.   

Abstract

In this study, the role of intercellular adhesion molecule 1 (ICAM-1) in the pathogenesis of Pseudomonas aeruginosa keratitis was examined by using inbred ICAM-1-deficient knockout mice. These mice had significantly less (P </= 0.02) ocular disease than wild-type mice, suggesting that ICAM-1 contributes to a more severe disease response following P. aeruginosa infection.

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Year:  1999        PMID: 9916118      PMCID: PMC96414     

Source DB:  PubMed          Journal:  Infect Immun        ISSN: 0019-9567            Impact factor:   3.441


  19 in total

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9.  Aged mice fail to upregulate ICAM-1 after Pseudomonas aeruginosa corneal infection.

Authors:  J A Hobden; S A Masinick; R P Barrett; L D Hazlett
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10.  Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice.

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