| Literature DB >> 9914454 |
A M Sullivan1, J Opacka-Juffry, J Pohl, S B Blunt.
Abstract
Growth/differentiation factor 5 (GDF5) is a neurotrophin which protects the rat nigrostriatal dopaminergic pathway from 6-hydroxydopamine-induced damage. Here we used amphetamine-induced rotational testing, high-performance liquid chromatography and immunocytochemistry to investigate the minimum effective dose of GDF5. We also compared the effectiveness of injecting GDF5 into either the substantia nigra pars compacta (SNpc), the lateral ventricle (LV) or the striatum (or combinations of these sites). Copyright 1999 Elsevier Science B.V.Entities:
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Year: 1999 PMID： 9914454 DOI： 10.1016/s0006-8993(98)01275-x
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252