Literature DB >> 99138

Formation and utilization of 3-hydroxy-3-methylglutarate in liver mitochondria of starved and streptozotocin-diabetic rats.

R Dena, M Fabbro, F Rigoni.   

Abstract

Kidney and liver mitochondria of rat, rabbit and guinea pig are able to transform 3-hydroxy-3-methylglutarate into acetoacetate, whereas ox liver mitochondria and rat mitochondria of heart, diaphragm and brain do not exhibit such an activity. Starvation and streptozotocin treatment decreases the formation of acetoacetate from 3-hydroxy-3-methylglutarate. Addition of acetoacetate and succinate to the incubation media of mitochondria results in a decrease in the transformation of 3-hydroxy-3-methylglutarate into acetoacetate. A 3-hydroxy-3-methylglutaryl-CoA hydrolase is present in rat liver mitochondria; the activity does not show appreciable changes after starvation or streptozotocin treatment.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 99138      PMCID： PMC1185710          DOI： 10.1042/bj1720371

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  15 in total

1.  A new and rapid colorimetric determination of acetylcholinesterase activity.

Authors:  G L ELLMAN; K D COURTNEY; V ANDRES; R M FEATHER-STONE
Journal:  Biochem Pharmacol       Date:  1961-07       Impact factor: 5.858

2.  [Methylglutaconase, a new hydrase participating in the metabolism of various carboxylic acids].

Authors:  H HILZ; J KNAPPE; E RINGELMANN; F LYNEN
Journal:  Biochem Z       Date:  1958

3.  A colorimetric method for the estimation of acetoacetate.

Authors:  P G WALKER
Journal:  Biochem J       Date:  1954-12       Impact factor: 3.857

4.  Utilization of branched chain acids in cholesterol synthesis.

Authors:  K BLOCH; L C CLARK; I HARARY
Journal:  J Biol Chem       Date:  1954-12       Impact factor: 5.157

5.  Biochemistry of fluoroacetate poisoning; the isolation and some properties of the fluorotricarboxylic acid inhibitor of citrate metabolism.

Authors:  R PETERS; R W WAKELIN
Journal:  Proc R Soc Lond B Biol Sci       Date:  1953-01-15

6.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

7.  Molecular and catalytic properties of cytosolic acetoacetyl coenzyme A thiolase from avian liver.

Authors:  K D Clinkenbeard; T Sugiyama; J Moss; W D Reed; M D Lane
Journal:  J Biol Chem       Date:  1973-04-10       Impact factor: 5.157

8.  3-Hydroxy-3-methylglutaric acid: protective action in experimental atherosclerosis in rabbits.

Authors:  P J Lupien; M Tremblay; Z H Beg
Journal:  Atherosclerosis       Date:  1973 Nov-Dec       Impact factor: 5.162

9.  Effect of dietary cholesterol and fasting on hepatic 3-hydroxy-3-methyl glutaryl coenzyme A hydrolase.

Authors:  M Saleemuddin; M Siddiqi
Journal:  Lipids       Date:  1972-09       Impact factor: 1.880

10.  Formation of acetoacetate from 3-hydroxy-3-methylglutarate by rat liver and isolation of a mitochondrial coenzyme A-transferase activity involved.

Authors:  R Deana; R Meneghello; L Manzi; C Gregolin
Journal:  Biochem J       Date:  1974-03       Impact factor: 3.857
View more
  1 in total

1.  IsoSearch: An Untargeted and Unbiased Metabolite and Lipid Isotopomer Tracing Strategy from HR-LC-MS/MS Datasets.

Authors:  He Huang; Min Yuan; Phillip Seitzer; Susan Ludwigsen; John M Asara
Journal:  Methods Protoc       Date:  2020-07-30
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.