| Literature DB >> 9894885 |
G S Scott1, L B Jakeman, B T Stokes, C Szabó.
Abstract
Peroxynitrite formation and the subsequent activation of the nuclear enzyme, poly (adenosine diphosphate [ADP]-ribose) synthetase (PARS), has been implicated in the pathogenesis of several neurodegenerative disorders. Here, we demonstrate that nitrotyrosine, an indicator of peroxynitrite generation, and poly (ADP) ribose, a marker of PARS activation, were selectively localized within tissues from spinal cord-injured rats. Our data implicate a role for peroxynitrite production and PARS activation in the development of spinal cord trauma.Entities:
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Year: 1999 PMID： 9894885
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422