| Literature DB >> 989362 |
R Sornay, J Gurrieri, C Tourne, F J Renson, B Majoie, E Wülfert.
Abstract
A systematic antilipidemic structure-activity relationship study was carried out on a series of alcoyl- and benzoyl-phenoxy-carboxylic acids. The introduction of a p-chlorobenzoyl moiety into the original phenoxy-isobutyric acid enhanced antilipidemic activity significantly. Chlorine meta substitution or chlorine disubstitution abolished activity. Among the esters synthetized, the isopropylester has been selected for further studies.Entities:
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Year: 1976 PMID： 989362
Source DB: PubMed Journal: Arzneimittelforschung ISSN： 0004-4172