Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2.

We report the genomic organization, mapping, and tissue distribution of the human inhibitors of apoptosis, HIAP1 and HIAP2. HIAP1 is 8.7 kb in length and is contained within eight coding and two non-coding (5'UTR) exons. The 4.5-kb HIAP2 message is contained within eight coding region exons and a single 5'UTR exon. The HIAP1 and HIAP2 genes lie in tandem on Chromosome (Chr) 11 (q22-23) with the intergenic distance being approximately 7 kb. The tissue distributions of HIAP1 and HIAP2 appear similar although the relative expression of HIAP1 is generally higher. Expression is highest in the kidney, small intestine, liver, and lung and lowest in tissues of the central nervous system.