| Literature DB >> 9892090 |
K Yamamoto1, M Hagino, H Kotaki, T Iga.
Abstract
A sensitive and selective analytical method for the determination of domperidone in rat plasma is described. The procedure involves liquid-liquid extraction followed by reversed-phase high-performance chromatographic analysis with fluorometric detection at 282 nm for excitation and 328 nm for emission. The detection limit was 1 ng ml(-1) using 1 ml of plasma. This assay procedure should be useful for the pharmacokinetic study of domperidone in small animals such as rats.Entities:
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Year: 1998 PMID： 9892090 DOI： 10.1016/s0378-4347(98)00339-9
Source DB: PubMed Journal: J Chromatogr B Biomed Sci Appl ISSN： 1387-2273