Application of chiral chromatographic parameters in quantitative structure-activity relationship analysis of homologous malathion derivatives.

The conditions of the chiral resolution of the racemic malathion O,O-di-n-alkyl derivatives on cellulose tris(3,5-dimethylphenylcarbamate) are described. Quantitative relationships between chromatographic parameters obtained on chiral and achiral stationary phases and acute toxicity of the compounds towards house fly are derived and discussed.