Literature DB >> 9891466

Immunolocalization of transforming growth factor-beta s and type I and type II receptors in rat articular cartilage.

K Fukumura1, S Matsunaga, T Yamamoto, T Nagamine, Y Ishidou, T Sakou.   

Abstract

The activities of TGF-beta s and their receptors (T beta R) in the articular cartilage have not been fully elucidated as yet. Temporal and spatial expression of TGF-beta s and their receptors were examined immunohistochemically in the articular cartilage of growing rats to clarify their role in chondrogenesis. TGF-beta 1, -beta 2 and -beta 3 were strongly expressed from 6 to 50 weeks in the superficial, transitional, and least mature zones. The expression of TGF-beta s in hypertrophic chondrocyte was weak except TGF-beta 1. T beta R-I and T beta R-II were co-expressed with the ligand in the superficial, transitional, and least mature zones throughout the growth phase. This study revealed that TGF-beta s in the articular cartilage plays a major role in the modulation of endochondral ossification ensuring the growth and maintenance of the chondrocyte lineage in articular cartilage.

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Year:  1998        PMID： 9891466

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  7 in total

1.  Expression of transforming growth factor-beta isoforms and their receptors in chronic tendinosis.

Authors:  S A Fenwick; V Curry; R L Harrall; B L Hazleman; R Hackney; G P Riley
Journal:  J Anat       Date:  2001-09       Impact factor: 2.610

2.  Low-level laser therapy (LLLT; 780 nm) acts differently on mRNA expression of anti- and pro-inflammatory mediators in an experimental model of collagenase-induced tendinitis in rat.

Authors:  Débora Pires; Murilo Xavier; Tiago Araújo; José Antônio Silva; Flavio Aimbire; Regiane Albertini
Journal:  Lasers Med Sci       Date:  2010-08-25       Impact factor: 3.161

3.  Transforming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E(2) production.

Authors:  Elena V Tchetina; John Antoniou; Michael Tanzer; David J Zukor; A Robin Poole
Journal:  Am J Pathol       Date:  2006-01       Impact factor: 4.307

4.  Regulation of immature cartilage growth by IGF-I, TGF-beta1, BMP-7, and PDGF-AB: role of metabolic balance between fixed charge and collagen network.

Authors:  Anna Asanbaeva; Koichi Masuda; Eugene J-M A Thonar; Stephen M Klisch; Robert L Sah
Journal:  Biomech Model Mechanobiol       Date:  2007-08-29

5.  Abnormal expression of Col X, PTHrP, TGF-beta, bFGF, and VEGF in cartilage with Kashin-Beck disease.

Authors:  Xiong Guo; Hong Zuo; Chun-Xia Cao; Yan Zhang; Dong Geng; Zeng-Tie Zhang; Yin-Gang Zhang; Klaus von der Mark; Helga von der Mark
Journal:  J Bone Miner Metab       Date:  2006       Impact factor: 2.976

6.  TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage.

Authors:  X Yang; L Chen; X Xu; C Li; C Huang; C X Deng
Journal:  J Cell Biol       Date:  2001-04-02       Impact factor: 10.539

7.  Evaluation of transforming growth factor beta 1 in dogs with osteoarthritis.

Authors:  Stephan Neumann; Sarah Lauenstein-Bosse
Journal:  Open Vet J       Date:  2018-10-25
  7 in total

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