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Literature DB >> 9889416

TRAIL induces apoptosis and activation of NFkappaB.

Abstract

TRAIL (TNF-related-apoptosis-inducing-ligand) was found as a new member of the TNF family which mediates cell death in a wide variety of malignant cell lines and primary tumor cells. TRAIL induces two different signals, cell death mediated by caspases and gene induction mediated by NFkappaB. Inhibition of TRAIL-induced activation of NFkappaB augments apoptosis induction by TRAIL and attenuates apoptosis resistance.

Entities: Disease Gene

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Year: 1998 PMID： 9889416

Source DB: PubMed Journal: Eur Cytokine Netw ISSN： 1148-5493 Impact factor: 2.737

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Cited

13 in total

Review 1. Immunobiology of tumor necrosis factor receptor superfamily.

Authors: Tong Zhou; John D Mountz; Robert P Kimberly
Journal: Immunol Res Date: 2002 Impact factor: 2.829

2. Reovirus infection activates JNK and the JNK-dependent transcription factor c-Jun.

Authors: P Clarke; S M Meintzer; C Widmann; G L Johnson; K L Tyler
Journal: J Virol Date: 2001-12 Impact factor: 5.103

3. The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase.

Authors: Y Lin; A Devin; A Cook; M M Keane; M Kelliher; S Lipkowitz; Z G Liu
Journal: Mol Cell Biol Date: 2000-09 Impact factor: 4.272

4. Killing effect of TNF-related apoptosis inducing ligand regulated by tetracycline on gastric cancer cell line NCI-N87.

Authors: X C Wei; X J Wang; K Chen; L Zhang; Y Liang; X L Lin
Journal: World J Gastroenterol Date: 2001-08 Impact factor: 5.742

10. Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes.

Authors: Deborah A Flusberg; Jérémie Roux; Sabrina L Spencer; Peter K Sorger
Journal: Mol Biol Cell Date: 2013-05-22 Impact factor: 4.138

TRAIL induces apoptosis and activation of NFkappaB.

Review 1. Immunobiology of tumor necrosis factor receptor superfamily.

2. Reovirus infection activates JNK and the JNK-dependent transcription factor c-Jun.

3. The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase.

4. Killing effect of TNF-related apoptosis inducing ligand regulated by tetracycline on gastric cancer cell line NCI-N87.

5. Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells.

Review 6. The TRAIL to targeted therapy of breast cancer.

7. Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism involving caspase-8 activation.

8. Kurarinone promotes TRAIL-induced apoptosis by inhibiting NF-κB-dependent cFLIP expression in HeLa cells.

9. Apoptosis and the airway epithelium.

10. Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes.